Human Cytomegalovirus

1. Front Matter

   Pages i-xiii

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2. Human Cytomegalovirus Genome

   • E. Murphy, Thomas E. Shenk

   Pages 1-19

3. Human Cytomegalovirus microRNAs

   • P. J. Fannin Rider, W. Dunn, E. Yang, F. Liu

   Pages 21-39

4. Mutagenesis of the Cytomegalovirus Genome

   • Z. Ruzsics, U. H. Koszinowski

   Pages 41-61

5. Cytomegalovirus Cell Tropism

   • C. Sinzger, M. Digel, G. Jahn

   Pages 63-83

6. Virus Entry and Innate Immune Activation

   • M. K. Isaacson, L. K. Juckem, T. Compton

   Pages 85-100

7. Functions of Human Cytomegalovirus Tegument Proteins Prior to Immediate Early Gene Expression

   • R. F. Kalejta

   Pages 101-115

8. Initiation of Cytomegalovirus Infection at ND10

   • G. G. Maul

   Pages 117-132

9. Functional Roles of the Human Cytomegalovirus Essential IE86 Protein

   • Mark F. Stinski, D. T. Petrik

   Pages 133-152

10. Nuts and Bolts of Human Cytomegalovirus Lytic DNA Replication

    • G. S. Pari

    Pages 153-166

11. Interactions of Human Cytomegalovirus Proteins with the Nuclear Transport Machinery

    • T. Stamminger

    Pages 167-185

12. Structure and Formation of the Cytomegalovirus Virion

    • W. Gibson

    Pages 187-204

13. Human Cytomegalovirus Modulation of Signal Transduction

    • A. D. Yurochko

    Pages 205-220

14. Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses

    • P. S. Beisser, H. Lavreysen, C. A. Bruggeman, C. Vink

    Pages 221-242

15. Subversion of Cell Cycle Regulatory Pathways

    • V. Sanchez, D. H. Spector

    Pages 243-262

16. Modulation of Host Cell Stress Responses by Human Cytomegalovirus

    • J. C. Alwine

    Pages 263-279

17. Control of Apoptosis by Human Cytomegalovirus

    • A. L. McCormick

    Pages 281-295

18. Aspects of Human Cytomegalovirus Latency and Reactivation

    • M. Reeves, J. Sinclair

    Pages 297-313

19. Murine Model of Cytomegalovirus Latency and Reactivation

    • M. J. Reddehase, C. O. Simon, C. K. Seckert, N. Lemmermann, N. K. A. Grzimek

    Pages 315-331

20. Cytomegalovirus Immune Evasion

    • C. Powers, V. DeFilippis, D. Malouli, K. Früh

    Pages 333-359

The earliest observation of cytomegalovirus (CMV) interactions with the host cell was owl eye cytopathology in various tissues. It was recognized in the early 1970s that human CMV caused in utero infections resulting in congenital brain damage and other sensory neurological complications. Events of the 1980s and early 1990s, such as the wide application of solid organ and bone marrow transplantation and the emergence of AIDS, put the spotlight on human CMV. We understood that the virus was an opportunistic agent associated with immunosuppression. The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes.

• Chemokine
• apoptosis
• cell
• gene
• infection
• placenta
• protein
• proteins
• vaccine
• virus

• Princeton University, Princeton, USA

  Thomas E. Shenk

• University of Iowa, Iowa, USA

  Mark F. Stinski

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