Editors:
- Includes supplementary material: sn.pub/extras
Part of the book series: Research and Perspectives in Alzheimer's Disease (ALZHEIMER)
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Table of contents (13 chapters)
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Front Matter
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Back Matter
About this book
During most of the 20th century, neurodegenerative diseases remained among the most enigmatic disorders of medicine. The scientific study of these conditions was descriptive in nature, detailing the clinical and neuropathological phenotypes associated with various diseases, but etiologies and pathogenic mechanisms remained obscure. Beginning in the 1970s, advances in two principal areas – biochemical pathology and molecular genetics – combined to yield powerful clues to the molecular underpinnings of several previously "idiopathic" brain disorders. Among the classical neurodegenerative diseases, perhaps the most rapid progress occurred in research on Alzheimer’s disease (AD). In disorders like Huntington’s disease, amyotrophic lateral sclerosis and even Parkinson’s disease, unbiased genetic screens, linkage analysis and positional cloning have identified causative genes that subsequently allowed the formulation of specific biochemical hypotheses. In sharp contrast, modern research on AD developed in the opposite order: the identification of the protein subunits of the classical brain lesions guided geneticists to disease-inducing genes, for example, APP, apolipoprotein E and tau. Thus, a biochemical hypothesis of disease - that AD is a progressive cerebral amyloidosis caused by the aggregation of the amyloid b-protein (Ab) - preceded and enabled the discovery of etiologies.
Editors and Affiliations
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Center for Neurologic Diseases, Brigham andWomen’s Ho, Harvard Medical School, Boston, USA
Dennis J. Selkoe
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Laboratoire de Biologie Cellulaire de la Synapse, Institut National de la Santé et de la Recherche, Médicale Unite 789, Paris, France
Antoine Triller
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Pour la Recherche Thérapeutique, Fondation IPSEN, Paris Cedex 16, France
Yves Christen
Bibliographic Information
Book Title: Synaptic Plasticity and the Mechanism of Alzheimer's Disease
Editors: Dennis J. Selkoe, Antoine Triller, Yves Christen
Series Title: Research and Perspectives in Alzheimer's Disease
DOI: https://doi.org/10.1007/978-3-540-76330-7
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2008
Hardcover ISBN: 978-3-540-76329-1Published: 11 January 2008
Softcover ISBN: 978-3-642-09519-1Published: 30 November 2010
eBook ISBN: 978-3-540-76330-7Published: 08 January 2008
Series ISSN: 0945-6066
Series E-ISSN: 2196-310X
Edition Number: 1
Number of Pages: XII, 183
Number of Illustrations: 8 b/w illustrations, 26 illustrations in colour
Topics: Neurosciences, Human Physiology