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Humanized Mice

  • Book
  • © 2008

Overview

Editors:
  1. Tatsuji Nomura

    1. Central Institute for Experimental Animals, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Takeshi Watanabe

    1. RIKEN, Japan

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    You can also search for this editor in PubMed   Google Scholar

  3. Sonoko Habu

    1. Tokai University School of Medicine, Japan

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 324)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Basic Concept of Development and Practical Application of Animal Models for Human Diseases

    • Tatsuji Nomura, N. Tamaoki, A. Takakura, H. Suemizu
    Pages 1-24

  3. Humanized SCID Mouse Models for Biomedical Research

    • T. Pearson, D. L. Greiner, L. D. Shultz
    Pages 25-51

  4. NOD/Shi-scid IL2rγnull (NOG) Mice More Appropriate for Humanized Mouse Models

    • M. Ito, K. Kobayashi, T. Nakahata
    Pages 53-76

  5. Humanizing Bone Marrow in Immune-Deficient Mice

    • K. Ando, Y. Muguruma, T. Yahata
    Pages 77-86

  6. The Differentiative and Regenerative Properties of Human Hematopoietic Stem/Progenitor cells in NOD-SCID/IL2rγnull Mice

    • F. Ishikawa, Y. Saito, S. Yoshida, M. Harada, L. D. Shultz
    Pages 87-94

  7. Antigen-Specific Antibody Production of Human B Cells in NOG Mice Reconstituted with the Human Immune System

    • M. Ito, M. Shiina, Y. Saito, Y. Tokuda, Y. Kametani, Sonoko Habu
    Pages 95-107

  8. Humanized Immune System (HIS) Mice as a Tool to Study Human NK Cell Development

    • N. D. Huntington, J. P. Di Santo
    Pages 109-124

  9. Human T Cell Development and HIV Infection in Human Hemato-Lymphoid System Mice

    • S. Baenziger, P. Ziegler, L. Mazzucchelli, L. Bronz, R. F. Speck, M. G. Manz
    Pages 125-131

  10. Humanized Mice for Human Retrovirus Infection

    • Y. Koyanagi, Y. Tanaka, M. Ito, N. Yamamoto
    Pages 133-148

  11. Functional and Phenotypic Characterization of the Humanized BLT Mouse Model

    • A. K. Wege, M. W. Melkus, P. W. Denton, J. D. Estes, J. V. Garcia
    Pages 149-165

  12. Novel Metastasis Models of Human Cancer in NOG Mice

    • M. Nakamura, H. Suemizu
    Pages 167-177

  13. In Vivo Imaging in Humanized Mice

    • H. Masuda, H. J. Okano, T. Maruyama, Y. Yoshimura, H. Okano, Y. Matsuzaki
    Pages 179-196

  14. Back Matter

    Pages 197-199
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Keywords

About this book

The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.

Editors and Affiliations

  • Central Institute for Experimental Animals, Japan

    Tatsuji Nomura

  • RIKEN, Japan

    Takeshi Watanabe

  • Tokai University School of Medicine, Japan

    Sonoko Habu

Bibliographic Information

  • Book Title: Humanized Mice

  • Editors: Tatsuji Nomura, Takeshi Watanabe, Sonoko Habu

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-540-75647-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2008

  • Hardcover ISBN: 978-3-540-75646-0Published: 11 April 2008

  • Softcover ISBN: 978-3-642-42077-1Published: 23 September 2014

  • eBook ISBN: 978-3-540-75647-7Published: 11 March 2008

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIII, 199

  • Topics: Immunology, Human Genetics, Human Physiology

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