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RNA Interference

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 320)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
  2. RNA Interference in Mammalian Cell Systems

    • Patrick J. Paddison
    Pages 1-19
  3. RNAi Pathway in C. elegans: The Argonautes and Collaborators

    • Marie-Eve L. Boisvert, Martin J. Simard
    Pages 21-36
  4. Genetics and Biochemistry of RNAi in Drosophila

    • Harsh H. Kavi, Harvey Fernandez, Weiwu Xie, James A. Birchler
    Pages 37-75
  5. Role of Dicer in Posttranscriptional RNA Silencing

    • Lukasz Jaskiewicz, Witold Filipowicz
    Pages 77-97
  6. MicroRNA Metabolism in Plants

    • Xuemei Chen
    Pages 117-136
  7. Structure-Function Relationships Among RNA-Dependent RNA Polymerases

    • Kenneth K.-S. Ng, Jamie J. Arnold, Craig E. Cameron
    Pages 137-156
  8. RNAi-Mediated Chromatin Silencing in Fission Yeast

    • Sharon A. White, Robin C. Allshire
    Pages 157-183
  9. A Role for RNAi in Heterochromatin Formation in Drosophila

    • Nicole C. Riddle, Sarah C. R. Elgin
    Pages 185-209
  10. Identifying Human MicroRNAs

    • Isaac Bentwich
    Pages 257-269
  11. Back Matter

    Pages 271-276

About this book

In the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems for the first time in academia and industry. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.

Editors and Affiliations

  • Cold Spring Harbor Laboratory, Cold Spring Harbor Fellows Program, Cold Spring Harbor

    Patrick J. Paddison

  • Department of Molecular & Experimental Medicine Division of Oncovirology, The Scripps Research Institute, La Jolla, USA

    Peter K. Vogt

Bibliographic Information

  • Book Title: RNA Interference

  • Editors: Patrick J. Paddison, Peter K. Vogt

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-540-75157-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2008

  • Hardcover ISBN: 978-3-540-75156-4Published: 17 December 2007

  • Softcover ISBN: 978-3-642-44445-6Published: 23 September 2014

  • eBook ISBN: 978-3-540-75157-1Published: 01 January 2008

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VIII, 273

  • Topics: Human Genetics, Medical Microbiology, Immunology

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access