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Control of Biofilm Infections by Signal Manipulation

  • Book
  • © 2008

Overview

Editors:
  1. Naomi Balaban
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  • Provides novel approaches and solutions to biofilm infections that are largly untreatable by using conventional approaches and antibiotics
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Series on Biofilms (BIOFILMS, volume 2)

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Table of contents (10 chapters)

  1. Front Matter

    Pages ii-xvi
    Download chapter PDF

  2. Introduction

    • Naomi Balaban, Dacheng Ren, Michael Givskov, Thomas Bovbjerg Rasmussen
    Pages 1-11

  3. Bacterial Cell-to-cell Communication (Quorum Sensing)

    • Michael Givskov, Thomas Bovbjerg Rasmussen, Dacheng Ren, Naomi Balaban
    Pages 13-38

  4. Detection In Vitro of Quorum-Sensing Molecules and Their Inhibitors

    • Robert J.C. McLean, Sandra A. Bryant, Dhiraj A. Vattem, Michael Givskov, Thomas Bovbjerg Rasmussen, Naomi Balaban
    Pages 39-50

  5. Quorum-Sensing Inhibitory Compounds

    • Dacheng Ren, Michael Givskov, Thomas Bovbjerg Rasmussen, Naomi Balaban
    Pages 51-77

  6. Mathematical Modeling of Quorum-Sensing Control in Biofilms

    • John Ward
    Pages 79-108

  7. Animal Models Commonly Used to Study Quorum-Sensing Inhibitors

    • Naomi Balaban, Michael Givskov, Thomas Bovbjerg Rasmussen, Andrea Giacometti, Oscar Cirioni
    Pages 109-117

  8. In Vivo Studies: Inhibiting Biofilm-Associated Bacterial Infections Using QSIs

    • Naomi Balaban, Michael Givskov, Thomas Bovbjerg Rasmussen
    Pages 119-129

  9. Quorum Sensing in Streptococci

    • M. Dilani Senadheera, Fengxia Qi, Dennis Cvitkovitch
    Pages 131-140

  10. Ironing Out the Biofilm Problem:The Role of Iron in Biofilm Formation

    • E. Peter Greenberg, Ehud Banin
    Pages 141-156

  11. Clinical Wound Healing Using Signal Inhibitors

    • Randall D. Wolcott
    Pages 157-170

  12. Back Matter

    Pages 171-175
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About this book

In the well-watered groves of academe, most of us are content to gather worshipful students and technicians in a shady nook to contemplate the eternal verities and to plan extravagant feasts to celebrate our contributions to “knowledge” and to the gradual improvement of the human condition. As one convocation follows another, and as our funding agencies pump billions of dollars into incremental research that ?lls every possible pigeon-hole in which a gene makes a protein, a small number of intellectual athletes seize a pivotal concept and plunge into the real world. It is this small band of nimble and impossibly brave intellectual halfbackswho win gamesin the real world, and this book is the result of the drive and intellectual athleticism of its editor and several of her contributors. Bacteria affect humans more than any other life forms with which we share the blue planet, but our understandingof these invisible companionshas developed in a staggering pattern, crippled by our panic and consequent shifts of emphasis. When our race was threatened by epidemic diseases, we visualized bacteria as swarms of potentially lethal planktoniccells from which we must remain isolated by sanitation and which we had to kill by immunization and chemical antibacterial compounds. By the time this overriding threat had been obviated, we began to examine na- ral and pathogenic ecosystems by direct methods, and we were surprised to ?nd that planktonic bacteria are comparatively rare and that most prokaryotes grow in matrix-enclosedbio?lms.

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