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Protein-Protein Interactions as New Drug Targets

  • Book
  • © 2008

Overview

Editors:
  1. Enno Klussmann

    1. Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. John Scott

    1. The Vollum Institute, Oregon Health & Science University, Portland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 186)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Organization of Scaffolds

    1. A-Kinase Anchoring Proteins as the Basis for cAMP Signaling

      • K. L. Dodge-Kafka, A. Bauman, M. S. Kapiloff
      Pages 3-14

    2. Arrestins as Multi-Functional Signaling Adaptors

      • V. V. Gurevich, E. V. Gurevich, W. M. Cleghorn
      Pages 15-37

    3. Role of Ena/VASP Proteins in Homeostasis and Disease

      • G. Pula, M. Krause
      Pages 39-65

    4. Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy

      • A. Gluch, M. Vidakovic, J. Bode
      Pages 67-103

    5. Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?

      • C. Rodemer, V. Haucke
      Pages 105-122

  3. Scaffolding Proteins and Cellular Signalling

    1. PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases

      • A. C. McCahill, E. Huston, X. Li, M. D. Houslay
      Pages 125-166

    2. G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains

      • H. H. Patel, F. Murray, P. A. Insel
      Pages 167-184

    3. Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design

      • J. W. Walker
      Pages 185-203

    4. Compartmentalised MAPK Pathways

      • M. D. Brown, D. B. Sacks
      Pages 205-235

    5. Dynamic Protein Complexes Regulate NF-κB Signaling

      • E. Wegener, D. Krappmann
      Pages 237-259

    6. An Oncogenic Hub: β-Catenin as a Molecular Target for Cancer Therapeutics

      • K. -I. Takemaru, M. Ohmitsu, F. -Q. Li
      Pages 261-284

    7. A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling

      • M. Berrera, G. Dodoni, S. Monterisi, V. Pertegato, I. Zamparo, M. Zaccolo
      Pages 285-298

  4. Cell Type-Specific Anchoring

    1. Scaffolding Proteins in Cardiac Myocytes

      • N. L. Chudasama, S. O. Marx, S. F. Steinberg
      Pages 301-325

    2. Molecular Architecture of Signal Complexes Regulating Immune Cell Function

      • K. M. Torgersen, E. M. Aandahl, K. Taskén
      Pages 327-363

    3. Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework

      • H. -J. Kreienkamp
      Pages 365-380

  5. Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept

    1. Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies

      • S. Costa, G. Cesareni
      Pages 383-405

    2. Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition

      • C. Freund, H. -G. Schmalz, J. Sticht, R. Kühne
      Pages 407-429

    3. Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors

      • S. W. Deacon, J. R. Peterson
      Pages 431-460

    4. Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs

      • H. M. Strauss, S. Keller
      Pages 461-482
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Keywords

About this book

Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions.

This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.

Editors and Affiliations

  • Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany

    Enno Klussmann

  • The Vollum Institute, Oregon Health & Science University, Portland, USA

    John Scott

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