Dendritic Cells

1. Front Matter

   Pages i-xvi

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2. Biology of Dendritic Cells

   1. Activation of Dendritic Cells by Toll-Like Receptors and C-Type Lectins

      • Sandra S. Diebold

      Pages 3-30

   2. Dendritic Cell Migration to Peripheral Lymph Nodes

      • Alfonso Martín-Fontecha, Antonio Lanzavecchia, Federica Sallusto

      Pages 31-49

   3. Dendritic Cells in Viral Infections

      • Gabrielle Belz, Adele Mount, Frederick Masson

      Pages 51-77

3. Role of Dendritic Cells in Disease

   1. Dendritic Cells and their Potential Implication in Pathology and Treatment of Rheumatoid Arthritis

      • M. H. Wenink, W. Han, R. E. M. Toes, T. R. D. J. Radstake

      Pages 81-98

   2. Lung Dendritic Cells: Targets for Therapy in Allergic Disease

      • Bart N. Lambrecht, Hamida Hammad

      Pages 99-114

   3. Dendritic Cells in Rhinitis

      • Alex KleinJan, Bart N. Lambrecht

      Pages 115-136

   4. Role of Epidermal Dendritic Cells in Drug-Induced Cutaneous Adverse Reactions

      • Maria Dolores Ramírez-González, Miguel Herrera-Enríquez, Luisa Geraldine Villanueva-Rodríguez, Andres Eliu Castell-Rodríguez

      Pages 137-162

4. Manipulation of Dendritic Cells for Immunotherapy

   1. T Cell Regulatory Plasmacytoid Dendritic Cells Expressing Indoleamine 2,3 Dioxygenase

      • David J. Kahler, Andrew L. Mellor

      Pages 165-196

   2. Aspirin and the Induction of Tolerance by Dendritic Cells

      • Matthew Buckland, Giovanna Lombardi

      Pages 197-213

   3. Use of Rapamycin in the Induction of Tolerogenic Dendritic Cells

      • Ryan Fischer, Heth R. Turnquist, Timuçin Taner, Angus W. Thomson

      Pages 215-232

   4. Handbook of Experimental Pharmacology “Dendritic Cells”

      • Cees van Kooten, Annelein S. Stax, Andrea M. Woltman, Kyra A. Gelderman

      Pages 233-249

   5. Induction of Tolerogenic Dendritic Cells by Vitamin D Receptor Agonists

      • Luciano Adorini, Giuseppe Penna

      Pages 251-273

   6. Use of Adenovirus in Vaccines for HIV

      • Steven Patterson, Timos Papagatsias, Adel Benlahrech

      Pages 275-293

   7. IFN-alpha in the Generation of Dendritic Cells for Cancer Immunotherapy

      • Stefano Maria Santini, Caterina Lapenta, Laura Santodonato, Giuseppina D'Agostino, Filippo Belardelli, Maria Ferrantini

      Pages 295-317

   8. Dendritic Cell-Based Immunotherapy in Myeloid Leukaemia: Translating Fundamental Mechanisms into Clinical Applications

      • A. A. van de Loosdrecht, W. van den Ancker, I. Houtenbos, G. J. Ossenkoppele, T. M. Westers

      Pages 319-348

5. Back Matter

   Pages 349-353

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The understanding of the role of dendritic cells (DCs) in immune responses has come a long way since Steinmann and colleagues described these cells in 1972. - tensive research during the intervening period has provided a good understanding of the complexity of the DC system and its pivotal role in immunity. It is also now clearer how different subsets of DCs interact and regulate each other and how DC populations affect the function of other cells of the immune system. The improved understanding of their role in immune response has led to the idea that modulation of DC functions by, for example, pharmacological agents could be used as a pot- tial therapeutic approach in some pathological conditions. The actual applicability and therapeutic potential of all these approaches is yet to be fully demonstrated but nonetheless, animal models of human diseases are proving to be very helpful in the evaluation of manipulated DCs as a new treatment in diseases like cancer, auto- munity or asthma. DCs are integral to the initiation and regulation of immune response (Banchereau et al. 2000). The outcome of antigen presentation by DCs is determined by their maturation status, which can be induced by their interaction with danger signals. To recognise a wide array of pathogen-associated molecular patterns (PAMP), DCs express a number of pattern recognition receptors (PRR) such as Toll-like rec- tors (TLRs) and C-type lectin receptors (CLR) that recognise structural components of pathogens and discriminate between self and non-self molecules.

• Dendritic Cells
• HIV
• Human Diseases
• Immunotherapy
• Migration
• Tolerance
• Transplantation
• Viral Immunity
• infections

• DIIID, King's College, London School of Medicine, Guy's Hospital, London, UK

  Giovanna Lombardi

• 5th Floor Hodgkin Building, School of Biomedical and Health Sciences, King's College London, London, United Kingdom

  Yanira Riffo-Vasquez

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