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cGMP: Generators, Effectors and Therapeutic Implications

  • Book
  • © 2009

Overview

Editors:
  1. Harald H. H. W. Schmidt

    1. Dept. Pharmacology, Monash University, Clayton, Australia

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    You can also search for this editor in PubMed   Google Scholar

  2. Franz Hofmann

    1. Inst. Pharmakologie und Toxikologie, TU München, München, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Johannes-Peter Stasch

    1. Bayer Schering Pharma AG Cardiology Research, Pharma Research Center, Wuppertal, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 191)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Basic Generators and Effectors

    1. A Short History of cGMP, Guanylyl Cyclases, and cGMP-Dependent Protein Kinases

      • Alexander Y. Kots, Emil Martin, Iraida G. Sharina, Ferid Murad
      Pages 1-14

    2. Biochemistry of Soluble Guanylate Cyclase

      • Emily R. Derbyshire, Michael A. Marletta
      Pages 17-31

    3. Genetic Mouse Models of the NO Receptor ‘Soluble’ Guanylyl Cyclases

      • Evanthia Mergia, Doris Koesling, Andreas Friebe
      Pages 33-46

    4. Function and Dysfunction of Mammalian Membrane Guanylyl Cyclase Receptors: Lessons from Genetic Mouse Models and Implications for Human Diseases

      • Michaela Kuhn
      Pages 47-69

    5. Phosphodiesterases in the Central Nervous System

      • Thomas Kleppisch
      Pages 71-92

    6. Structural and Biochemical Aspects of Tandem GAF Domains

      • Joachim E. Schultz
      Pages 93-109

    7. Cyclic Nucleotide-Gated Channels

      • Martin Biel, Stylianos Michalakis
      Pages 111-136

    8. cGMP Regulated Protein Kinases (cGK)

      • Franz Hofmann, Dominik Bernhard, Robert Lukowski, Pascal Weinmeister
      Pages 137-162

    9. cGK Substrates

      • Jens Schlossmann, Matthias Desch
      Pages 163-193

    10. Biochemical Detection of cGMP From Past to Present: An Overview

      • Peter M. Schmidt
      Pages 195-228

    11. Novel Techniques for Real-Time Monitoring of cGMP in Living Cells

      • Viacheslav O. Nikolaev, Martin J. Lohse
      Pages 229-243

  3. Pharmacology of cGMP

    1. NO and sGC-Stimulating NO Donors

      • Ian L. Megson, Mark R. Miller
      Pages 247-276

    2. NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators

      • Johannes-Peter Stasch, Adrian J. Hobbs
      Pages 277-308

    3. NO- and Haem-Independent Soluble Guanylate Cyclase Activators

      • Harald H. H. W. Schmidt, Peter M. Schmidt, Johannes-Peter Stasch
      Pages 309-339

    4. Natriuretic Peptides: Their Structures, Receptors, Physiologic Functions and Therapeutic Applications

      • Lincoln R. Potter, Andrea R. Yoder, Darcy R. Flora, Laura K. Antos, Deborah M. Dickey
      Pages 341-366

    5. Cyclic GMP-Hydrolyzing Phosphodiesterases

      • Sharron H. Francis, Jackie D. Corbin, Erwin Bischoff
      Pages 367-408

    6. cGMP-Dependent Protein Kinase Modulators

      • Elke Butt
      Pages 409-421

    7. cGMP-Dependent Protein Kinase as a Modifier of Behaviour

      • Christopher J. Reaume, Marla B. Sokolowski
      Pages 423-443

  4. Clinical Applications

    1. cGMP in the Vasculature

      • Barbara Kemp-Harper, Harald H. H. W. Schmidt
      Pages 447-467
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Keywords

About this book

After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.

Editors and Affiliations

  • Dept. Pharmacology, Monash University, Clayton, Australia

    Harald H. H. W. Schmidt

  • Inst. Pharmakologie und Toxikologie, TU München, München, Germany

    Franz Hofmann

  • Bayer Schering Pharma AG Cardiology Research, Pharma Research Center, Wuppertal, Germany

    Johannes-Peter Stasch

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