The Maturation Phenomenon, described by Ito et al. in 1975 [3) on the basis of his to logical observations in the hippocampus as well as other portions of the cerebral hemisphere, refers to the hours or days of delay in the development of pathological changes in various parameters of ischemic injury following the restoration of blood flow to the ischemic brain. There is a direct relationship between the intensity of ischemic insult and the speed and rate of maturation of ischemic injury, a lesser intensity being associated with slower and less severe development of the lesions. The delayed neuronal death of CAl pyramidal cells of the hippocampus [8) is a classic example. In the cerebral cortex, with increasing intensity of the ischemic insult, the maturation phenomenon of ischemic injuries intensifies, seamlessly, from less exten sive to more extensive disseminated selective neuronal necrosis (DSNN), and then further to cerebral infarction upon reaching a critical threshold [1,2,4,6,7). We also have found that following ischemic insults just under the threshold level required to induce infarction, only disseminated selective neuronal necrosis (DSNN) progresses, while following ischemic insults at the threshold level, initially only DSNN develops, followed by the evolution of a gradually enlarging infarcted focus [5, 7). The reporting of this phenomenon boosted research in the field, as it became evi dent that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention.
Editors and Affiliations
Department of Neurosurgery, Musashino Red Cross Hospital, Tokyo 180, Japan
Umeo Ito
Dipartimenti di Scienze Neurologiche, Università di Roma “La Sapienza”, Roma, Italy
Cesare Fieschi
Istituto Neurologico Mediterraneo, NEUROMED Research Laboratories, Pozzilli (Isernia), Italy
Francesco Orzi
Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 113 Tokyo, Japan
Toshihiko Kuroiwa
National Institutes of Health, Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, Bethesda, USA
Igor Klatzo
Bibliographic Information
Book Title: Maturation Phenomenon in Cerebral Ischemia III
Book Subtitle: Defensive Mechanisms Versus Apoptosis Neuronal Recovery and Protection in Cerebral Infarction
Editors: Umeo Ito, Cesare Fieschi, Francesco Orzi, Toshihiko Kuroiwa, Igor Klatzo
