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The Role of Microenvironment in Axonal Regeneration

Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the Postcommissural Fornix

  • Book
  • © 1997

Overview

Authors:
  1. Christine C. Stichel-Gunkel

    1. Molekulare Neurobiologie, Neurologische Klinik, Universität Düsseldorf, Düsseldorf, Germany

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Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 137)

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Table of contents (6 chapters)

  1. Front Matter

    Pages I-VIII
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  2. Introduction

    • Christine C. Stichel-Gunkel
    Pages 1-8

  3. Aims of the Study

    • Christine C. Stichel-Gunkel
    Pages 9-9

  4. Materials and Methods

    • Christine C. Stichel-Gunkel
    Pages 11-18

  5. Results

    • Christine C. Stichel-Gunkel
    Pages 19-44

  6. Discussion

    • Christine C. Stichel-Gunkel
    Pages 45-58

  7. Summary and Perspectives

    • Christine C. Stichel-Gunkel
    Pages 59-59

  8. Back Matter

    Pages 61-81
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Keywords

About this book

Since the pioneering studies of Ramon y Cajal the inability of lesioned adult CNS axons to regenerate has been well established. During the past years advancements in molecular, cellular and biochemical knowledge have provided new insights into the extrinsic mechanims underlying regeneration failure. The rapid progress in this field has already led to the development of new concepts for therapeutic manipulations. This book provides a comprehensive overview of structural and molecular changes induced by an invasive CNS lesion and their involvements in regeneration processes. Moreover, it demonstrates the strong growth-promoting actitivies of implanted glial cells. The data is discussed in relation to current knowledge on the mechanisms of axonal degeneration and regeneration and in terms of their relevance for the development of novel therapeutic strategies.

Authors and Affiliations

  • Molekulare Neurobiologie, Neurologische Klinik, Universität Düsseldorf, Düsseldorf, Germany

    Christine C. Stichel-Gunkel

Bibliographic Information

  • Book Title: The Role of Microenvironment in Axonal Regeneration

  • Book Subtitle: Influences of Lesion-Induced Changes and Glial Implants on the Regeneration of the Postcommissural Fornix

  • Authors: Christine C. Stichel-Gunkel

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-642-60781-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1997

  • Softcover ISBN: 978-3-540-62787-6Published: 19 June 1997

  • eBook ISBN: 978-3-642-60781-3Published: 06 December 2012

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: VIII, 82

  • Number of Illustrations: 18 b/w illustrations

  • Topics: Neurosciences, Animal Physiology

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