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Thrombolytic Therapy in Acute Ischemic Stroke II

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. Gregory J. Zoppo

    1. Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, La Jolla, USA

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  2. Etsuro Mori

    1. Neurology Service, Hyogo Brain and Heart Center at Himeji, Himeji, 670, Japan

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  3. Werner Hacke

    1. Neurologische Klinik, Ruprecht-Karls-Universität Heidelberg, Heidelberg 1, Germany

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Table of contents (52 papers)

  1. Front Matter

    Pages I-XIV
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  2. Background to Thrombolytic Therapy in Acute Ischemic Stroke

    1. Front Matter

      Pages 1-1
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    2. Therapy for Acute Ischemic Stroke: Clinical Needs and Statistical Burdens

      • L. R. Caplan, M. Gent
      Pages 3-12

    3. Clinical Outcome of Acute Ischemic Stroke: Prospective Angiographic Studies

      • C. Fieschi, M. L. Sacchetti, C. Argentino, M. Fiorelli, D. Toni, C. Gori et al.
      Pages 13-16

    4. The Ischemic Penumbra: Usefulness of PET

      • W. J. Powers
      Pages 17-21

    5. Thrombolytic Agents: Lessons for Their Use in Acute Stroke from Myocardial Infarction Experience

      • M. Verstraete
      Pages 22-28

    6. Pathogenesis of Secondary Brain Hemorrhage After Ischemia: Lessons from Animal Models … and a few from man: too!

      • G. F. Molinari
      Pages 29-36

  3. Clinical Trials of Fibrinolytic Agents in Carotid Territory Cerebral Ischemia

    1. Front Matter

      Pages 37-37
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    2. Symptom-Based Trials of Intravenous rt-PA in Acute Stroke

      • T. Brott
      Pages 39-44

    3. A Safety and Efficacy Study of Intravenous rt-PA in Patients with Acute Stroke

      • M. J. Alberts
      Pages 45-52

    4. Recanalization, Infarct Volume, Cerebral Hemorrhage, and Clinical Outcome After Intravenous Recombinant Tissue Plasminogen Activator and Heparin in Acute Carotid Territory Stroke

      • R. von Kummer, M. Forsting, W. Hacke, K. Sartor
      Pages 53-58

    5. Intravenous Tissue Plasminogen Activator in Acute Thromboembolic Stroke: A Placebo-Controlled, Double-Blind Trial

      • T. Yamaguchi, T. Hayakawa, H. Kikuchi
      Pages 59-65

    6. The European Cooperative Acute Stroke Study (ECASS)

      • M. Kaste, C. Fieschi, W. Hacke, E. Lesaffre, M. Verstraete, J. Fröhlich
      Pages 66-71

    7. On the Estimation of the Sample Size for the ECASS Study

      • E. Lesaffre, I. Scheys, J. Fröhlich, E. Bluhmki
      Pages 72-79

    8. Australian Streptokinase Trial (ASK)

      • G. A. Donnan, S. M. Davis, B. R. Chambers, P. C. Gates, G. J. Hankey, E. G. Stewart-Wynne et al.
      Pages 80-85

    9. Thrombolytic and Antithrombotic Therapy in Acute Ischemic Stroke. Multicenter Acute Stroke Trial — Italy (MAST-I)

      • Gregory J. del Zoppo, Etsuro Mori, Werner Hacke
      Pages 86-94

    10. Discussion Summary: Clinical Trials in Progress

      • G. Boysen
      Pages 95-99

  4. Other Applications of Fibrinolytic Agents in the Central Nervous System

    1. Front Matter

      Pages 101-101
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    2. Acute Central Retinal Artery Occlusion and the Role of Thrombolysis

      • H.-J. Freitag, H. Zeumer, V. Knospe
      Pages 103-105

    3. Current Status of Fibrinolysis for the Rapid Dissolution of Subarachnoid and Intraventricular Clot

      • B. Weir
      Pages 106-113
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Keywords

About this book

Over the last decade, interest in treatment of ischemic stroke has increased significantly. Perhaps the single most important feature of attempts to improve the outcome of stroke patients has been that the interventions be applied within the very early hours of stroke symptoms. This has spawned efforts to understand the vascular and neuronal responses to cerebral artery reperfusion experimentally. Important prospective clinical studies of thrombolysis in acute ischemic stroke have been completed, and large placebo-controlled, symptom-based studies are now underway worldwide. Here, we consider the central features of those studies, their experimental basis, and the future importance of adjunctive therapies to recanalization in focal brain ischemia acutely. Risks and benefits are discussed. This collection benefits from the opinions of experts and workers in this rapidly evolving and exciting field.

Editors and Affiliations

  • Department of Molecular and Experimental Medicine, The Scripps Research Institute and Division of Hematology/Medical Oncology, Scripps Clinic and Research Foundation, La Jolla, USA

    Gregory J. Zoppo

  • Neurology Service, Hyogo Brain and Heart Center at Himeji, Himeji, 670, Japan

    Etsuro Mori

  • Neurologische Klinik, Ruprecht-Karls-Universität Heidelberg, Heidelberg 1, Germany

    Werner Hacke

Bibliographic Information

  • Book Title: Thrombolytic Therapy in Acute Ischemic Stroke II

  • Editors: Gregory J. Zoppo, Etsuro Mori, Werner Hacke

  • DOI: https://doi.org/10.1007/978-3-642-78061-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-540-56442-3Published: 03 June 1993

  • eBook ISBN: 978-3-642-78061-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 334

  • Number of Illustrations: 36 b/w illustrations

  • Topics: Neurology, Intensive / Critical Care Medicine, Neuroradiology

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