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Prostaglandin E1

New Aspects on Pharmacology, Metabolism and Clinical Efficacy

  • Conference proceedings
  • © 1991

Overview

Editors:
  1. Curt Diehm

    1. Med. Klinik im Rehabilitationskrankenhaus Karlsbad, Karlsbad, Germany

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  2. Helmut Sinzinger

    1. Wilhelm-Auerswald-Atheroskleroseforschungsgruppe Wien, Wien, Germany

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    You can also search for this editor in PubMed   Google Scholar

  3. Waltraud Rogatti

    1. Köln 91, Germany

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Table of contents (13 papers)

  1. Front Matter

    Pages I-XI
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  2. Cellular Sites of Action of Prostaglandins in the Cardiovascular System

    • K. Schrör
    Pages 1-5

  3. On the Metabolism and Pharmacokinetics of Prostaglandin E1 Administered by Intra-arterial or Intravenous Infusions

    • B. A. Peskar, W. H. Hesse, W. Rogatti, G. Rudofsky
    Pages 6-11

  4. Actions of PGE1, PGE0 and 15-keto-PGE1 on Vessel Tone in Vitro

    • M. Braun, L. Bruch, P. Ney, G. Torsello, K. Schrör
    Pages 12-20

  5. 13,14-dihydro-PGE1 (PGE0) but not 15-keto-PGE1 is a Potent Inhibitor of Human Platelet and Neutrophil Activation

    • P. Ney, M. Braun, C. Szymanski, K. Schrör
    Pages 21-32

  6. Comparable Inhibitory Action of PGE1 and 13,14-dihydro-PGE1 on Smooth Muscle Cell Activity and Extracellular Matrix Production

    • I. Neumann, P. Fitscha, J. O’grady, B. A. Peskar, H. Sinzinger
    Pages 33-38

  7. PGE1 and 13,14-dihydro-PGE1 Increase Low-Density Lipoprotein Receptors and Improve Arterial Wall Lipid Metabolism

    • H. Sinzinger, I. Virgolini, G. Lupattelli, M. Banyai
    Pages 39-48

  8. Effect of Intra-arterial and Intravenous Application of Prostaglandin E1 on Neutrophil Function in Peripheral Arterial Occlusive Disease

    • F.-J. Neumann, T. Weiss, J. Mollenhauer, M. Schneider, I. Ott, H.-M. Haupt et al.
    Pages 49-57

  9. A Comparison of Different Dosages of Intra-arterial and Intravenous Administered Prostaglandin E1 in Healthy Volunteers

    • G. Rudofsky, B. A. Peskar
    Pages 58-71

  10. Transcutaneous Oxygen Pressure at Different Dosages of Intravenous Prostaglandin E1 in Patients with Severe Arterial Occlusive Disease: A Double-Blind, Placebo-Controlled Study

    • A. Creutzig, L. Caspary, K. Alexander
    Pages 72-81

  11. Transcutaneous PO2 During Intra-arterial and Intravenous PGE1 Infusion in Patients with Critical Limb Ischaemia

    • T. Weiss, J. Griesshaber, W. Rogatti, O. Kistner, E. Hsu, T. Jansen et al.
    Pages 82-90

  12. Effects of Intravenous PGE1 on Blood Flow and Microcirculation: A Double-Blind, Placebo-Controlled Study in Patients with Critical Limb Ischaemia

    • P. Scheffler, D. de la Hamette, G. Leipnitz, J. Gross
    Pages 91-100

  13. Therapeutic Efficacy of Intravenous Prostaglandin E1 Versus Pentoxifylline in Patients with Intermittent Claudication

    • W. Hepp, S. von Bary, D. Corovic, C. Diehm, E. Mühe, G. Rudofsky et al.
    Pages 101-108

  14. Adjuvant Intravenous PGE1 Treatment After Profundaplasty for Limb Salvage

    • J. D. Gruss
    Pages 109-113

  15. Back Matter

    Pages 115-117
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Keywords

About this book

Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour­ able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic , endothelium-stabilizing and leucocyte-stabi­ 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13,14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE . Being 1 biologically active, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very closely resembles that of PGE . This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given intravenously.

Editors and Affiliations

  • Med. Klinik im Rehabilitationskrankenhaus Karlsbad, Karlsbad, Germany

    Curt Diehm

  • Wilhelm-Auerswald-Atheroskleroseforschungsgruppe Wien, Wien, Germany

    Helmut Sinzinger

  • Köln 91, Germany

    Waltraud Rogatti

Bibliographic Information

  • Book Title: Prostaglandin E1

  • Book Subtitle: New Aspects on Pharmacology, Metabolism and Clinical Efficacy

  • Editors: Curt Diehm, Helmut Sinzinger, Waltraud Rogatti

  • DOI: https://doi.org/10.1007/978-3-642-76910-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-540-54524-8Published: 20 January 1992

  • eBook ISBN: 978-3-642-76910-8Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 117

  • Topics: Pharmacology/Toxicology, Metabolic Diseases, Allergology, Immunology, Cardiology

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