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Transdermal Fentanyl

A New Approach to Prolonged Pain Control

  • Conference proceedings
  • © 1991

Overview

Editors:
  1. Klaus A. Lehmann

    1. Institut für Anaesthesiologie und Operative Intensivmedizin, Universität Köln, Köln 41, Germany

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  2. Detlev Zech

    1. Institut für Anaesthesiologie und Operative Intensivmedizin, Universität Köln, Köln 41, Germany

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Table of contents (16 papers)

  1. Front Matter

    Pages I-XI
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  2. Transdermal Therapeutic Systems — An Introduction

    1. Front Matter

      Pages XIII-XIII
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    2. Transdermal Permeation: Physiological and Physicochemical Aspects

      • S. S. Hwang, K. C. Nichols, M. Southam
      Pages 1-7

    3. Transdermal Therapeutic Systems in Clinical Use: Development and Applications

      • W. S. Nimmo
      Pages 8-14

  3. Current Aspects of Pain Management

    1. Front Matter

      Pages 15-15
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    2. Postoperative Pain

      • K. A. Lehmann, S. Grond, D. Zech
      Pages 17-35

    3. Cancer Pain

      • R. Payne
      Pages 36-41

    4. Pain Management and Quality of Life in Cancer Patients

      • C. M. Moinpour, C. R. Chapman
      Pages 42-63

    5. Opioid Analgesia for Chronic, Nonmalignant Pain

      • M. Strumpf, M. Zenz
      Pages 64-70

  4. Noninvasive Fentanyl Application

    1. Front Matter

      Pages 71-71
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    2. Pharmacokinetics of Fentanyl

      • L. E. Mather, G. K. Gourlay
      Pages 73-97

    3. Premedication and Pain Management with Oral Transmucosal Fentanyl

      • J. B. Streisand
      Pages 98-106

    4. Transdermal Fentanyl: an Overview of Pharmacokinetics, Efficacy and Safety

      • M. Southam, S. Gupta, M. Knowles, S. S. Hwang
      Pages 107-116

  5. Postoperative Pain Management with TTS Fentanyl

    1. Front Matter

      Pages 117-117
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    2. Pharmacokinetics and Pharmacodynamics

      • G. K. Gourlay, L. E. Mather
      Pages 119-140

    3. Clinical Experience

      • B. von Borman
      Pages 141-148

    4. Respiratory Safety

      • L. Latasch, R. Christ
      Pages 149-157

    5. TTS Fentanyl in Combination with Patient-Controlled Analgesia

      • C. Einnolf, H. J. Eberlein, K. A. Lehmann
      Pages 158-167

  6. Cancer Pain Management with TTS Fentanyl

    1. Front Matter

      Pages 169-169
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    2. Clinical Experience

      • D. Zech, S. Grond, J. Lynch
      Pages 171-187
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Keywords

About this book

That pain is a serious clinical problem, which requires considerable effortsby physicians and the nursing staff, has been stressed in numerous publications. Transdermal application is well known for a variety of drugs, including cardiovascular drugs, antiemetics and hormones. Some years ago, first experience was also made with transdermally administered opiates from which the transdermal therapeutic system (TTS) fentanyl has now been approved by the American Food and Drug Administration. The book presents the results of the first international workshop "Transdermal Fentanyl", held September 27 -28, 1990 in Cologne, FRG. This workshop was intended to facilitate a critical evaluation of theoretical and clinical studies with the new, non-invasive fentanyl application and to provide an opportunity for an exchange of ideas about its value for pain management, anaesthesiology and future investigations in this field. Topics covered by the book are physiology of transdermal permeation, experience with other transdermal systems, the present state of acute and chronic pain management and experimental and clinical studies with transdermal fentanyl, with special concern to analgesic efficacy and side effects. Readers will easily find out that the experts appreciated transdermal analgesia but also warned against an uncritical optimism. TTS fentanyl can be a valuable tool in the clinicians' armentarium against pain. It should be kept in mind, however, that it represents a new administration mode, not a new drug, and that the sustained, non-invasive application requires well reflected diagnosis and good general standards of pain management.

Editors and Affiliations

  • Institut für Anaesthesiologie und Operative Intensivmedizin, Universität Köln, Köln 41, Germany

    Klaus A. Lehmann, Detlev Zech

Bibliographic Information

  • Book Title: Transdermal Fentanyl

  • Book Subtitle: A New Approach to Prolonged Pain Control

  • Editors: Klaus A. Lehmann, Detlev Zech

  • DOI: https://doi.org/10.1007/978-3-642-76872-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-540-54440-1Published: 31 October 1991

  • eBook ISBN: 978-3-642-76872-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIII, 203

  • Number of Illustrations: 14 b/w illustrations

  • Topics: Anesthesiology, Pain Medicine, Pharmacology/Toxicology, Oncology

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