Shock, Sepsis, and Organ Failure

1. Front Matter

   Pages I-X

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2. Gut as a Source of Organ Failure

   1. Front Matter

      Pages 1-1

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   2. Hypoxic Damage of the Gut in Shock

      • U. Haglund

      Pages 3-22

   3. Experimental Evidence of Bacterial Translocation in Trauma

      • Edwin A. Deitch

      Pages 23-52

   4. Bacterial Translocation in a Baboon Model of Hypovolemic-Traumatic Shock

      • G. Schlag, H. Redl, H. P. Dinges, J. Davies, K. Radmore

      Pages 53-90

   5. Bacterial Translocation Across a Histologically Intact Intestinal Mucosa

      • C. L. Wells, S. L. Erlandsen, D. L. Dunn, R. L. Simmons

      Pages 91-117

   6. Clinical Evidence of Bacterial Translocation from the Gut

      • B. F. Rush Jr., J. N. McCullough

      Pages 118-132

   7. Role of Bacterial Translocation and Selective Gut Decontamination in the Development of Multiple Organ Failure

      • R. J. A. Goris, I. P. T. van Bebber, Th. Hendriks

      Pages 133-146

3. Metabolic Aspects of the Liver in Sepsis

   1. Front Matter

      Pages 147-147

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   2. The Liver as Modulator of the Host-Defense Response: Host-Defense Failure Disease as a Manifestation of Hepatic Decompensation

      • John H. Siegel

      Pages 149-206

   3. Concepts of Liver Protein Metabolism in Sepsis

      • P. O. Hasselgren, D. von Allmen, J. E. Fischer

      Pages 207-234

   4. Increased Glucose Uptake and Superoxide Anion Production after Priming or Activation of Hepatic Phagocytes: A Potential Source of Liver Damage

      • John J. Spitzer, Zoltan Spolarics, Abraham P. Bautista, Károly Mészáros, Agnes Schuler, Charles H. Lang

      Pages 235-254

   5. Modulation of Hepatic Function in Endotoxemia by Intercellular Communication

      • J. A. Spitzer

      Pages 255-275

4. Endothelium as a Target in Sepsis

   1. Front Matter

      Pages 277-277

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   2. Cytokine-Dependent Interleukin-8 Expression and its Role in Cell Communication

      • Steven L. Kunkel, Theodore Standiford, Robert M. Strieter

      Pages 279-296

   3. Trauma and Sepsis Induced Activation of Granulocytes, Monocytes/Macrophages and Endothelial Cells in Primates

      • H. Redl, G. Schlag, H. P. Dinges, S. Bahrami, W. A. Buurman, U. Schade et al.

      Pages 297-322

   4. Molecular Mechanisms of Neutrophil-Mediated Pulmonary Microvascular Injury: Role of Adhesion Proteins

      • Asrar B. Malik

      Pages 323-350

   5. Pathogenetic Linkages between Gram Negative Septic Shock and the Cellular Initiation and Regulation of Coagulation

      • Thomas S. Edgington

      Pages 351-369

   6. Sepsis, Disseminated Intravascular Coagulation and Multiorgan Failure: Catastrophic Events in Severe Burns

      • H. A. Linares

      Pages 370-398

   7. Mechanisms of Vascular Impairment During Endotoxaemia with Special Reference to the Role of the L-arginine Pathway

      • I. Fleming, B. L. Furman, G. A. Gray, M. O. Guc, G. Julou-Schaeffer, M. Bigaud et al.

      Pages 399-424

The Wiggers Bernard Conferences, named after two great physiologists of the past, are an­ nual gatherings of the leaders in the field of shock. The meetings focus on specific areas of which appears to be showing the most advancement during the previous year. There are se­ veral types of sessions; informal presentations during which the seminarian can be intenup­ ted in order to clarify a particular point; formal discussions follow each presentation; these are followed by informal gatherings in which these discussions continue during meals and libation in a very relaxed environment. The 1990 meeting took place in Durnstein, Austria. A small hamlet in the wine growing area of the Wachau valley, on the Danube above Vien­ na. This was the site of a former citadel where the English King Richard the Lion-Heart (Coeur de Uon) was held for ransom during the middle ages. The frank beauty and hospi­ tality of this area in addition to the ancient Roman adage "in vino veritas" acted as a catalyst to crystalize the thoughts of this interdisciplinary group of scientists as they discussed the following areas: 1. Gut as a Source of Organ Failure 2. Metabolic Aspects of the Liver in Sepsis 3. Endothelium as a Target'in Sepsis We would like to thank the participants of the conference for taking time away from their very productive and busy schedules to participate in the conference and for the prompt pre­ sentation of their manuscripts and editions of their discussions.

• Mikrobiologie
• Organversagen
• Pathophysiologie
• Trauma
• bacteria
• metabolism
• microbiology
• organ failure
• pathophysiology
• sepsis
• infectious diseases

• Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Wien, Austria

  Günther Schlag, Heinz Redl

• Maryland Institute for Emergency Medical Services Systems, Department of Surgery, Medical School, University of Maryland, Baltimore, USA

  John H. Siegel

• School of Medicine, John Hopkins University, Baltimore, USA

  John H. Siegel

• Shriners Burns Institute and The University of Texas Medical Branch, Galveston, USA

  Daniel L. Traber

Policies and ethics