Cancer Metastasis

1. Front Matter

   Pages I-XIV

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2. Opening Plenary Lectures

   1. Front Matter

      Pages 1-1

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   2. Metastasis: The Clinical Problem

      • E. V. Sugarbaker, D. N. Seckinger, O. O. Frankfurt

      Pages 3-10

   3. The Nude Mouse Model for Studies of Human Cancer Metastasis

      • I. J. Fidler

      Pages 11-17

3. Genetic Control of Tumor Progression

   1. Front Matter

      Pages 19-19

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   2. Tumor Cells Genetically Tagged with Transferred DNA Markers Reveal Evidence for Clonal Dominance of Primary Tumors by Metastatic Subpopulations

      • R. S. Kerbel, C. Waghorne, B. Korczak, M. L. Breitman

      Pages 21-26

   3. Oncogenes and Tumor Progression: State of the Art

      • F. M. Van Roy, M. M. Mareel

      Pages 27-35

   4. Genetic Analysis of Invasive and Metastatic Capacity in T Lymphoma Cells

      • G. G. M. Habets, J. G. Collard

      Pages 36-41

   5. Transforming Growth Factor-Beta: Possible Roles in Carcinogenesis

      • K. C. Flanders, M. B. Sporn, A. B. Roberts

      Pages 42-47

   6. Altered Gene Expression in Tumor Metastasis: The nm23 Gene

      • P. S. Steeg, G. Bevilacqua, A. M. Rosengard, M. E. Sobel, V. Cioce, L. A. Liotta

      Pages 48-52

4. Metastatic Phenotype and Cell Differentiation

   1. Front Matter

      Pages 53-53

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   2. In Vivo Observations on Tumor Invasion

      • H. E. Gabbert

      Pages 55-61

   3. Metastatic Phenotype and Cell Differentiation in Melanoma Cells

      • I. R. Hart, R. E. Wilson

      Pages 62-67

5. Organotropism: Adhesion, Invasion, Angiogenesis, Homing, Growth Factors

   1. Front Matter

      Pages 69-69

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   2. Adhesive, Invasive, and Growth Properties of Organ-Specific Metastatic Cells

      • G. L. Nicolson

      Pages 71-85

   3. Importance of Cell Surface Carbohydrates in Tumor Cell Metastasis

      • J. W. Dennis, S. Laferté

      Pages 86-91

   4. Cell Shape and the Metastatic Phenotype

      • I. R. Nabi, A. Raz

      Pages 92-97

   5. Cell Surface Plasminogen Activation

      • K. Danø, N. Behrendt, L. R. Lund, E. Rønne, J. Pöllänen, E.-M. Salonen et al.

      Pages 98-107

   6. Adhesion Mechanisms in Lymphoma Invasion and Metastasis

      • F. F. Roossien, G. La Rivière, E. Roos

      Pages 108-112

   7. The Role of Macrophages in the Regulation of Tumor Growth and Metastasis

      • B. Bottazzi, R. Giavazzi, N. Nobili, F. Fazioli, A. Mantovani

      Pages 113-117

These are the Proceedings of the 2nd International Metastasis Congress of the Metastasis Research Society which took place in the town hall (Stadthalle) of Heidelberg, FRG, in September, 1988. This first Metastasis Congress in the FRG was organized in conjunction with the German Association of Cancer Research (SEK) of the German Cancer Society. The congress topic generated tremendous interest and attracted about 400 scientists from 22 countries. Most participants came from Europe, Israel, and the United States. Why did we organize the Metastasis Congress? Only about 50% of all people who develop some form of cancer are curable. Despite improved patient care and increasingly innovative and effective techniques for diagnosing and treating primary cancers, the development of secondary cancer colonies, i. e. , metastasis, can not be prevented and is the major cause of death. In the Federal Republic of Germany there are still as many as 160 000 cancer patients per year who succumb to their disease, often after periods of terrible suffering, and this overall figure is not improving. Partly because of the complexity of the process, basic research on metastasis has lagged behind other disciplines such as carcino­ genesis and cancer genetics. Metastasis formation involves the ability of malig­ nant cells to invade adjacent tissue and to penetrate into lymphatic or blood circulatory systems, or both, and to spread to near or distant sites to form new tumor colonies. Meanwhile, research on metastasis is receiving much attention.

• Antigen
• angiogenesis
• interferon
• surgery
• transplantation
• tumor growth

• Institut für Immunologie und Genetik, DKFZ, Heidelberg, Germany

  Volker Schirrmacher, Reinhard Schwartz-Albiez

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