Genetic and Therapeutic Aspects of Lipid and Purine Metabolism

1. Front Matter

   Pages I-XIII

   PDF

2. Genetic Aspects

   1. Front Matter

      Pages 1-1

      PDF

   2. Lipid Metabolism

      1. DNA Polymorphisms in the Diagnosis of Familial Hypercholesterolemia

         • H. Schuster, B. Stiefenhofer, G. Rauh, R. Taylor, S. Humphries

         Pages 3-12

      2. Molekularbiologie und klinische Forschung: Das Beispiel des LDL-Rezeptors und der Familiären Hypercholesterinämie

         • T. C. Südhof

         Pages 13-17

      3. Genetics, Drugs and Low Density Lipoprotein Metabolism

         • C. J. Packard, J. Shepherd

         Pages 19-28

      4. Visualization and Characterization of the Scavenger Receptor in Human Liver

         • K. Harders-Spengel

         Pages 29-42

      5. Expression of Human Apo AI, AII and CII Genes in Pro- and Eukaryotic Cells

         • W. Stoffel, E. Binczek, A. Haase, C. Holtfreter

         Pages 43-56

   3. Purine Metabolism

      1. Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: Molecular Basis and Clinical Relevance

         • B. L. Davidson, T. D. Palella, W. N. Kelley

         Pages 57-66

      2. Molecular Basis of AMP Deaminase Isoform Diversity

         • R. L. Sabina, E. W. Holmes

         Pages 67-70

      3. Purine Excretion

         • R. Greger

         Pages 71-77

      4. Nephrolithiasis in the Context of Purine Metabolism

         • H. A. Simmonds

         Pages 79-90

3. Therapeutic Aspects

   1. Front Matter

      Pages 91-91

      PDF

   2. Hyperlipidemia

      1. Prognosis of Dyslipoproteinemia

         • P. Schwandt

         Pages 93-99

      2. Acute and Chronic Effects of Diet and Physical Exercise on Plasma Lipids

         • G. Schlierf, G. Schuler

         Pages 101-104

      3. Present Concepts for Drug Treatment of Hyperlipidaemia in Adults

         • H. Greten

         Pages 105-110

      4. Comparison of Different Forms of Plasmapheresis

         • C. Keller, G. Wolfram

         Pages 111-116

      5. Extracorporeal Plasma Therapy in the Treatment of Severe Hyper-β-Lipoproteinemia: The HELP System

         • D. Seidel

         Pages 117-128

      6. LDL Apheresis: 7 Years of Clinical Experience

         • H. Borberg, K. Oette, W. Stoffel

         Pages 129-136

   3. Disturbances of Purine Metabolism

      1. Clinical Aspects of Gout

         • H. F. Woods

         Pages 137-144

      2. Diet and Drug Treatment of Gout

         • W. Gröbner

         Pages 145-154

This publication of a symposium held on 24 th and 25 th of June 1988 in Munich th is dedicated to Nepomuk Zollner on the occasion of his 65 birthday, expressing the best wishes of the authors. Nepomuk Zollner was born in the northern part of Bavaria. While a medical student in Munich he was called up to military duty in the last year of World War II. After achieving excellent results on his examinations he served as a physician in several hospitals in Munich and soon became interested in inborn errors of metabolism. In order to receive the best education possible at that time he joined the group of S. J. Thannhauser, the famous German emigrant, in Boston where he worked from 1951 to 1953. There he was able to continue his studies on lipids, which he had started in 1948, and begin with his studies on purine metabolism. While working in Thannhauser's laboratory he learned to think and act according to the strict laws of natural SCIence. After returning to Europe he concentrated his scientific work on purines and lipids. Gout and hyperlipoproteinemias from the genetic to the therapeutic aspects remained the dominating topics of his research activities. In spite of many obligations as head of the Medical Polyclinic of the University of Munich and many activities at the university and in scientific societies Zollner's foremost intent continued to be the development and progress of natural science in medicine.

• Cholesterin
• DNA
• HIV
• Lipid
• Lipoprotein
• Purine
• biology
• clinical research
• enzymes
• lipide
• metabolism
• molecular biology
• protein
• receptor
• research

• Medizinische Poliklinik der Universität, München 2, Germany

  Günther Wolfram

• Institut für Ernährungswissenschaft in Weihenstephan, Technische Universität München, Freising, Germany

  Günther Wolfram

Policies and ethics