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The Calcium Channel: Structure, Function and Implications

Stresa/Italy, May 11–14, 1988

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Martin Morad

    1. Department of Physiology, University of Pennsylvania, Philadelphia, USA

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  2. Winifred G. Nayler

    1. Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Australia

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  3. Stanislav Kazda

    1. Bayer AG, Institute of Pharmacology, Wuppertal 1, Germany

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  4. Matthias Schramm

    1. Bayer AG, Institute of Pharmacology, Wuppertal 1, Germany

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Part of the book series: Bayer AG Centenary Symposium (BAYER)

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Table of contents (51 papers)

  1. Front Matter

    Pages I-XXVII
    Download chapter PDF

  2. History and Philosophy of Bayer Pharmaceutical Research

    1. History and Philosophy of Bayer Pharmaceutical Research

      • W.-D. Busse
      Pages 1-8

  3. The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882

    1. The Effect of Lime and Potash on the Frog Heart: An Imaginative Reconstruction of a Paper Presented by Sydney Ringer to the Physiological Society on 9th December 1882

      • R. A. Chapman
      Pages 9-15

  4. Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships

    1. Homology of Calcium-Modulated Proteins: Their Evolutionary and Functional Relationships

      • R. H. Kretsinger, N. D. Moncrief, M. Goodman, J. Czelusniak
      Pages 16-34

  5. The Function of Calcium Channel

    1. Front Matter

      Pages 37-37
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    2. Kinetics and β-Adrenergic Modulation of Cardiac Ca2+ Channels

      • W. Trautwein, D. Pelzer
      Pages 39-53

    3. Dihydropyridines, G Proteins, and Calcium Channels

      • A. M. Brown, L. Birnbaumer, A. Yatani
      Pages 54-62

    4. Electrophysiology of Dihydropyridine Calcium Agonists

      • M. Bechem, M. Schramm
      Pages 63-70

    5. Proton-Induced Transformation of Ca2+ Channel: Possible Mechanism and Physiological Role

      • M. Morad, G. Callewaert
      Pages 71-80

    6. Membrane Potential and Dihydropyridine Block of Calcium Channels in the Heart: Influence of Drug Ionization on Blocking Activity

      • R. S. Kass, J. P. Arena
      Pages 81-91

    7. Dihydropyridine-Sensitive and -Insensitive Ca2+ Channels in Normal and Transformed Fibroblasts

      • C. Chen, M. J. Corbley, T. M. Roberts, P. Hess
      Pages 92-102

    8. Protein Phosphorylation and the Inactivation of Dihydropyridine-Sensitive Calcium Channels in Mammalian Pituitary Tumor Cells

      • D. Kalman, D. L. Armstrong
      Pages 103-114

    9. Sodium Currents Through Neuronal Calcium Channels: Kinetics and Sensitivity to Calcium Antagonists

      • E. Carbone, H. D. Lux
      Pages 115-127

    10. Block of Sodium Currents Through a Neuronal Calcium Channel by External Calcium and Magnesium Ions

      • H. D. Lux, E. Carbone, H. Zucker
      Pages 128-137

    11. The Voltage Sensor of Skeletal Muscle Excitation-Contraction Coupling: A Comparison with Ca2+ Channels

      • G. Pizarro, G. Brum, M. Fill, R. Fitts, M. Rodriguez, I. Uribe et al.
      Pages 138-156

  6. The Structure of the Calcium Channel

    1. Front Matter

      Pages 157-157
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    2. Biochemistry and Molecular Pharmacology of Ca2+ Channels and Ca2+-Channel Blockers

      • J. Barhanin, M. Fosset, M. Hosey, C. Mourre, D. Pauron, J. Qar et al.
      Pages 159-167

    3. The Structure of the Ca2+ Channel: Photoaffinity Labeling and Tissue Distribution

      • H. Glossmann, J. Striessnig, L. Hymel, G. Zernig, H. G. Knaus, H. Schindler
      Pages 168-192

    4. Site-Specific Phosphorylation of the Skeletal Muscle Receptor for Calcium-Channel Blockers by cAMP-Dependent Protein Kinase

      • A. Röhrkasten, H. E. Meyer, T. Schneider, W. Nastainczyk, M. Sieber, H. Jahn et al.
      Pages 193-199

    5. Molecular Properties of Dihydropyridine-Sensitive Calcium Channels from Skeletal Muscle

      • M. J. Seagar, M. Takahashi, W. A. Catterall
      Pages 200-210
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Keywords

About this book

This is the first book to summarize experimental results from the new, rapidly expanding field of research into the calcium channel in cell membrane. Calcium is an ubiquitous messenger of various cellular functions. Its fundamental role in the regulation of cardiac contractions has long been recognized. Drugs counteracting some actions of calcium ions, namely calcium antagonists, have since become essential to research. In the last decade it has been established that calcium ions reach their target intracellular system by passing through specialized calcium channels in the membrane. Recently improved experimental techniques combined with the discovery of highly specific Ca channel ligands have dramatically enlarged our knowledge of the molecular structure and function of such channels. The contributions by leading world specialists shed new light on both basic science and possible clinical implications for cardiovascular pharmacology, endocrinology and neuropharmacology.

Editors and Affiliations

  • Department of Physiology, University of Pennsylvania, Philadelphia, USA

    Martin Morad

  • Department of Medicine, Austin Hospital, University of Melbourne, Heidelberg, Australia

    Winifred G. Nayler

  • Bayer AG, Institute of Pharmacology, Wuppertal 1, Germany

    Stanislav Kazda, Matthias Schramm

Bibliographic Information

  • Book Title: The Calcium Channel: Structure, Function and Implications

  • Book Subtitle: Stresa/Italy, May 11–14, 1988

  • Editors: Martin Morad, Winifred G. Nayler, Stanislav Kazda, Matthias Schramm

  • Series Title: Bayer AG Centenary Symposium

  • DOI: https://doi.org/10.1007/978-3-642-73914-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-540-50061-2Published: 24 November 1988

  • eBook ISBN: 978-3-642-73914-9Published: 06 December 2012

  • Series ISSN: 1431-116X

  • Edition Number: 1

  • Number of Pages: XXVII, 643

  • Number of Illustrations: 73 b/w illustrations

  • Topics: Pharmacology/Toxicology, Nephrology, Biochemistry, general

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