The Genetic Basis of Male Infertility

1. Front Matter

   Pages I-XIV

   PDF

2. Clinical Aspects of Male Infertility

   • Csilla Krausz, Gianni Forti

   Pages 1-21

3. The Cell Biology and Molecular Genetics of Testis Determination

   • Craig A. Smith, Andrew H. Sinclair

   Pages 23-52

4. The Sertoli Cell-Germ Cell Interactions and the Seminiferous Tubule InterIeukin-1 and lnterIeukin-6 System

   • B. Jégou, J. P. Stéphan, C. Cudicini, E. Gomez, F. Bauché, C. Piquet-Pellorce et al.

   Pages 53-68

5. Leydig Cell Function and Its Regulation

   • M. P. Hedger, D. M. de Kretser

   Pages 69-110

6. Post-transcriptional Control and Male Infertility

   • Robert E. Braun

   Pages 111-129

7. An Integration of Old and New Perspectives of Mammalian Meiotic Sterility

   • Terry Ashley

   Pages 131-173

8. Mutations of the Cystic Fibrosis Gene and Congenital Absence of the Vas Deferens

   • Pasquale Patrizio, Debra G. B. Leonard

   Pages 175-186

9. Mitochondrial Function and Male Infertility

   • Thomas Bourgeron

   Pages 187-210

10. The Human Y Chromosome and Male Infertility

    • Ken McElreavey, Csilla Krausz, Colin E. Bishop

    Pages 211-232

11. Spermatogenesis and the Mouse Y Chromosome: Specialisation Out of Decay

    • Michael J. Mitchell

    Pages 233-270

12. The Comparative Genetics of Human Spermatogenesis: Clues from Flies and Other Model Organisms

    • Ron Hochstenbach, Johannes H. P. Hackstein

    Pages 271-298

13. Back Matter

    Pages 299-305

    PDF

Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, Drosophila and mice provide a global overview of the field.

• Chromosom
• G proteins
• Genotyp
• Mutation
• Termination
• cell biology
• chromosome
• evolution
• genes
• genetics
• infertility
• nuclear receptors
• regulation
• transcription
• translation

• Immunogénétique Humaine, Institut Pasteur, Paris Cedex 15, France

  Ken McElreavey

Policies and ethics