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The Molecular Genetics of Aging

  • Book
  • © 2000

Overview

Editors:
  1. Siegfried Hekimi

    1. Department of Biology, McGill University, Montréal, Canada

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  • This book encompasses both classic epidemiological and molecular approaches to studying aging, and highlights current theories of aging
  • Includes supplementary material: sn.pub/extras

Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 29)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-XV
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  2. Centenarians and the Genetics of Longevity

    • Thomas Perls, Dellara F. Terry, Margery Silver, Maureen Shea, Jennifer Bowen, Erin Joyce et al.
    Pages 1-20

  3. Coordination of Metabolic Activity and Stress Resistance in Yeast Longevity

    • S. Michal Jazwinski
    Pages 21-44

  4. Current Issues Concerning the Role of Oxidative Stress in Aging: A Perspective

    • Rajindar S. Sohal, Robin J. Mockett, William C. Orr
    Pages 45-66

  5. Regulation of Gene Expression During Aging

    • Stephen L. Helfand, Blanka Rogina
    Pages 67-80

  6. Crossroads of Aging in the Nematode Caenorhabditis elegans

    • Siegfried Hekimi
    Pages 81-112

  7. Contributions of Cell Death to Aging in C. elegans

    • Laura A. Herndon, Monica Driscoll
    Pages 113-129

  8. Stress Response and Aging in Caenorhabditis elegans

    • Gordon J. Lithgow
    Pages 131-148

  9. Oxidative Stress and Aging in Caenorhabditis elegans

    • Naoaki Ishii, Philip S. Hartman
    Pages 149-164

  10. Mutation Accumulation In Vivo and the Importance of Genome Stability in Aging and Cancer

    • Martijn E. T. DollĂ©, Heidi Giese, Harry van Steeg, Jan Vijg
    Pages 165-180

  11. Delayed Aging in Ames Dwarf Mice. Relationships to Endocrine Function and Body Size

    • Andrzej Bartke
    Pages 181-202

  12. Stem Cells and Genetics in the Study of Development, Aging, and Longevity

    • Gary Van Zant
    Pages 203-235

  13. Back Matter

    Pages 237-240
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Keywords

About this book

The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu­ man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.

Editors and Affiliations

  • Department of Biology, McGill University, MontrĂ©al, Canada

    Siegfried Hekimi

Bibliographic Information

  • Book Title: The Molecular Genetics of Aging

  • Editors: Siegfried Hekimi

  • Series Title: Results and Problems in Cell Differentiation

  • DOI: https://doi.org/10.1007/978-3-540-48003-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2000

  • Softcover ISBN: 978-3-642-53686-1Published: 28 July 2012

  • eBook ISBN: 978-3-540-48003-7Published: 06 December 2012

  • Series ISSN: 0080-1844

  • Series E-ISSN: 1861-0412

  • Edition Number: 1

  • Number of Pages: XVI, 240

  • Number of Illustrations: 78 b/w illustrations, 28 illustrations in colour

  • Topics: Cell Biology, Biochemistry, general

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