Vertebrate Eye Development

1. Front Matter

   Pages I-XIV

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2. Overview

   1. Vertebrate Eye Development and Refractive Function: An Overview

      • Barbara Sivak, Jacob Sivak

      Pages 1-14

3. Early Pattern Formation

   1. Pax6 and the Genetic Control of Early Eye Development

      • Stefan Wawersik, Patricia Purcell, Richard L. Maas

      Pages 15-36

   2. Early Retinal Development in Drosophila

      • Ulrike Heberlein, Jessica E. Treisman

      Pages 37-50

4. Embryonic Induction

   1. Induction of the Lens

      • Nicolas Hirsch, Robert M. Grainger

      Pages 51-68

5. Retinal Differentiation

   1. Molecular Control of Cell Diversification in the Vertebrate Retina

      • Sabine Fuhrmann, Lely Chow, Thomas A. Reh

      Pages 69-91

   2. Cell Fate Specification in the Drosophila Retina

      • Justin P. Kumar, Kevin Moses

      Pages 93-114

   3. Roles of the Extracellular Matrix in Retinal Development and Maintenance

      • Richard T. Libby, William J. Brunken, Dale D. Hunter

      Pages 115-140

   4. Adhesive Events in Retinal Development and Function: The Role of Integrin Receptors

      • Dennis O. Clegg, Linda H. Mullick, Kevin L. Wingerd, Hai Lin, Jason W. Atienza, Amy D. Bradshaw et al.

      Pages 141-156

6. Formation of Neural Pathways for Vision

   1. Connecting the Eye with the Brain: The Formation of the Retinotectal Pathway

      • Karl G. Johnson, William A. Harris

      Pages 157-177

7. Regeneration

   1. Regeneration of the Lens in Amphibians

      • Panagiotis A. Tsonis

      Pages 179-196

   2. How the Neural Retina Regenerates

      • Pamela A. Raymond, Peter F. Hitchcock

      Pages 197-218

8. Genetic Models

   1. Mouse Mutants for Eye Development

      • Jochen Graw

      Pages 219-256

   2. Genetic Analysis of Eye Development in Zebrafish

      • Jarema Malicki

      Pages 257-282

9. Back Matter

   Pages 283-288

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"Who would believe that so small a space could contain the images of all the universe?" Leonardo da Vinci The last years of the 20th century have found the discipline of Developmental Biology returning to its original position at the forefront of biological re­ search. This progress can be attributed to the burgeoning knowledge base on molecules and gene families, and to the power of the molecular genetic ap­ proach. Topping the list of organ systems which have provided the most significant advances would have to be the eye. The vertebrate eye was one of the classic embryologic models, used to demonstrate many important prin­ ciples, including the concepts of inductive tissue interactions first put forth in the early 1900s. Within the last decade of this century, a return to some of the old questions with the new approaches has put eye development back into the limelight. I find this a highly appropriate topic for a book which aims to spark research for the new millennium. We begin with a chapter that discusses the anatomy of eye development, providing the basic reference information for the chapters that follow. A novel aspect of this introduction is the connection made between develop­ mental strategies and the eye's optical function. What also emerges from this chapter is the number of important eye structures that have barely been touched by the modern developmental biologist. Work on cornea and ante­ rior chamber development has lagged behind lens and retina.

• Auge
• Developmernt
• Drosophila
• Entwicklung
• Eye
• Invertebrate
• Miolecular Biology
• Molekularbiologie
• Regeneration
• Sehen
• Vertebrate
• Vision
• anatomy
• developmental biology

• Vision Research Laboratories, New England Eye Center, Tufts University School of Medicine, Boston, USA

  M. Elizabeth Fini

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