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Targeted Therapies in Cancer

  • Book
  • © 2007

Overview

Editors:
  1. Manfred Dietel

    1. Institut für Pathologie, Charité Humboldt-Universität zu Berlin, Berlin, Germany

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 176)

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Table of contents (21 chapters)

  1. Front Matter

    Pages I-XIV
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  2. Prediction of Tumor Behavior

    1. Front Matter

      Pages 1-1
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    2. Beyond Typing and Grading: Target Analysis in Individualized Therapy as a New Challenge for Tumour Pathology

      • Hans H. Kreipe, Reinhard von Wasielewski
      Pages 3-6

    3. Oncogenic Signaling Pathways and Deregulated Target Genes

      • Reinhold Schäfer, Anja Schramme, Oleg I. Tchernitsa, Christine Sers
      Pages 7-24

    4. Predictive Pathology of Cytostatic Drug Resistance and New Anti-cancer Targets

      • Manfred Dietel
      Pages 25-32

    5. Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract

      • Heinz Höfler, Rupert Langer, Katja Ott, Gisela Keller
      Pages 33-36

    6. Resistance-Associated Signatures in Breast Cancer

      • Balázs Györffy
      Pages 37-50

    7. Resistance to Chemotherapy in Ovarian Carcinoma

      • Hermann Lage, Carsten Denkert
      Pages 51-60

    8. Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer

      • Ulrike Stein, Peter M. Schlag
      Pages 61-80

    9. Prediction of Efficacy and Side Effects of Chemotherapy in Colorectal Cancer

      • Jan Stoehlmacher
      Pages 81-88

    10. Proteomic Expression Profiling of Breast Cancer

      • Hans Neubauer, Tanja Fehm, Christina Schütz, Runa Speer, Erich Solomayer, André Schrattenholz et al.
      Pages 89-120

  3. Targeted Therapy and Clinical Applications

    1. Front Matter

      Pages 121-121
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    2. Targeted Therapy and Blood-Brain Barrier

      • Agnieszka Korfel, Eckhard Thiel
      Pages 123-133

    3. Cetuximab: Appraisal of a Novel Drug Against Colorectal Cancer

      • Bert Hildebrandt, Philipp le Coutre, Annett Nicolaou, Konrad Kölble, Hanno Riess, Bernd Dörken
      Pages 135-143

    4. C-kit, GIST, and Imatinib

      • Jan Siehl, Eckhard Thiel
      Pages 145-151

    5. Antibody Therapy in Non-Hodgkin’s Lymphoma: The Role of Rituximab, 90Y-Ibritumomab Tiuxetan, and Alemtuzumab

      • Thomas Fietz, Eckhard Thiel
      Pages 153-163

    6. Molecular and Clinical Aspects of Proteasome Inhibition in the Treatment of Cancer

      • Ivana Zavrski, Christian Jakob, Martin Kaiser, Claudia Fleissner, Ulrike Heider, Orhan Sezer
      Pages 165-176

    7. Individualized Target Therapy of Malignant Lymphomas: An Outlook

      • Ioannis Anagnostopoulos
      Pages 177-188

    8. Antiangiogenesis, Anti-VEGF(R) and Outlook

      • Iver Petersen
      Pages 189-199

    9. Morphological Detection of Hormone and Growth Factor Receptors in Breast Cancer

      • Konrad Kölble
      Pages 201-209
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Keywords

About this book

From its introduction, oncological chemotherapy has been encumbered by its poor selectivity because most antiproliferative drugs are toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. The resultant problems with unwanted side effects are compounded by difficulties in predicting the desired effectivity of chemotherapy in individual patients.

This unsatisfactory situation has driven intensive research and development towards more specific and less toxic anticancer drugs over the last few decades. Several results of these efforts have reached the clinic and an even greater number are now in preclinical testing.

Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting the efficacy of the drug and personalizing therapy.

This book aims to present translational scientists and clinicians with an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

Editors and Affiliations

  • Institut für Pathologie, Charité Humboldt-Universität zu Berlin, Berlin, Germany

    Manfred Dietel

Bibliographic Information

  • Book Title: Targeted Therapies in Cancer

  • Editors: Manfred Dietel

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-540-46091-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2007

  • Hardcover ISBN: 978-3-540-46090-9Published: 08 June 2007

  • Softcover ISBN: 978-3-642-43243-9Published: 23 November 2014

  • eBook ISBN: 978-3-540-46091-6Published: 10 June 2007

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: XIV, 262

  • Topics: Oncology, Cancer Research

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