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Mitochondrial Function and Biogenesis

  • Book
  • © 2004

Overview

Editors:
  1. Carla Koehler

    1. University of California, Los Angeles Dept. Chemistry & Biochemistry, Los Angeles, USA

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  2. Matthias F. Bauer

    1. Klinikum Schwabing Institut für Diabetesforschung, München, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Covers the latest aspects of mitochondrial biogenesis, genome evolution, metabolism and energy generation
  • Provides a new link between basic mitochondrial research and mitochondrial medicine

Part of the book series: Topics in Current Genetics (TCG, volume 8)

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Table of contents (13 chapters)

  1. Front Matter

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  2. Mitochondrial genome evolution: the origin of mitochondria and of eukaryotes

    • Rachel B. Bevan, B. Franz Lang
    Pages 1-35

  3. Mitochondrial biogenesis: Protein import into and across the outer membrane

    • Doron Rapaport, Frank E. Nargang
    Pages 37-58

  4. Mitochondrial biogenesis. Protein import into and across the inner membrane

    • Sean P. Curran, Carla M. Koehler
    Pages 59-80

  5. Mitochondrial tRNA editing

    • Jens Schuster, Mario Mörl
    Pages 81-96

  6. Protein quality control in mitochondria and neurodegeneration in hereditary spastic paraplegia

    • Peter Bross, Elena I. Rugarli, Giorgio Casari, Thomas Langer
    Pages 97-121

  7. Defects in assembly of cytochrome oxidase: roles in mitochondrial disease

    • Fiona A. Punter, D. Moira Glerum
    Pages 123-148

  8. Function and dysfunction of the oxidative phosphorylation system

    • Leo G.J. Nijtmans, Cristina Ugalde, Lambert P. van den Heuvel, Jan A.M. Smeitink
    Pages 149-176

  9. MtDNA maintenance and stability genes: MNGIE and mtDNA depletion syndromes

    • Michio Hirano, Ramon Martí, Maya R. Vilà, Yutaka Nishigaki
    Pages 177-200

  10. Protein translocation into mammalian mitochondria and its role in the development of human mitochondrial disorders

    • Sabine Hofmann, Matthias F. Bauer
    Pages 201-225

  11. Mitochondrial fission and fusion machineries

    • Lorena Griparic, Brian Head, Alexander M. van der Bliek
    Pages 227-249

  12. VDAC function in a cellular context

    • Michael Forte
    Pages 251-266

  13. Lipid synthesis and transport in mitochondrial biogenesis

    • Dennis R. Voelker
    Pages 267-291

  14. From electron transfer to cholesterol transfer; molecular regulation of steroid synthesis in the mitochondrion

    • Colin Jefcoate, Irina Artemenko
    Pages 293-330

  15. Back Matter

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Keywords

About this book

Mitochondria are complex organelles, possessing a double-membrane and even their own genome, the mtDNA. They play a pivotal role in cellular metabolism, respiration, and production of ATP essential for the normal function of all human organ systems. It is not surprising, therefore, that genetic defects of mitochondrial functions cause a wide spectrum of human diseases. This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level.

The 13 contributions written by leading researchers in the field include topics such as: mitochondrial genome evolution and mtDNA stability, mitochondrial biogenesis and protein quality control, mitochondrial morphology, assembly and function of the mitochondrial energy generation apparatus and mitochondrial metabolic pathways. These are particularly oriented to link in these various mitochondrial pathways to the clinical consequences of their dysfunctions.

Editors and Affiliations

  • University of California, Los Angeles Dept. Chemistry & Biochemistry, Los Angeles, USA

    Carla Koehler

  • Klinikum Schwabing Institut für Diabetesforschung, München, Germany

    Matthias F. Bauer

Bibliographic Information

  • Book Title: Mitochondrial Function and Biogenesis

  • Editors: Carla Koehler, Matthias F. Bauer

  • Series Title: Topics in Current Genetics

  • DOI: https://doi.org/10.1007/b10825

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2004

  • Hardcover ISBN: 978-3-540-21489-2Published: 13 May 2004

  • Softcover ISBN: 978-3-642-05994-0Published: 15 December 2010

  • eBook ISBN: 978-3-540-40895-6Published: 03 March 2004

  • Series ISSN: 1610-2096

  • Series E-ISSN: 1610-6970

  • Edition Number: 1

  • Number of Pages: XVI, 333

  • Topics: Biochemistry, general, Cell Biology, Human Genetics

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