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Differentiation and Neoplasia

  • Book
  • © 1980

Overview

Editors:
  1. Robert G. McKinnell

    1. Department of Genetics and Cell Biology, University of Minnesota, St. Paul, USA

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  2. Marie A. DiBerardino

    1. Department of Anatomy, Medical College of Pennsylvania, Philadelphia, USA

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  3. Martin Blumenfeld

    1. Department of Genetics and Cell Biology, University of Minnesota, St. Paul, USA

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  4. Robert D. Bergad

    1. Department of Genetics and Cell Biology, University of Minnesota, St. Paul, USA

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Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 11)

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Table of contents (38 chapters)

  1. Front Matter

    Pages I-XVI
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  2. Cell Differentiation Yesterday and Today

    • J. Brachet
    Pages 1-7

  3. Gene Injections into Amphibian Oocytes

    • D. A. Melton, R. Cortese, E. M. de Robertis, M. F. Trendelenburg, J. B. Gurdon
    Pages 8-14

  4. Organization of Transcribed and Nontranscribed Chromatin

    • W. W. Franke, U. Scheer, H. Zentgraf, M. F. Trendelenburg, U. Müller, G. Krohne et al.
    Pages 15-36

  5. Visualization of Transcriptional Activity During Xenopus laevis Oogenesis

    • K. Martin, Y. N. Osheim, A. L. Beyer, O. L. Miller Jr.
    Pages 37-44

  6. Differential Histone Phosphorylation During Drosophila Development

    • M. Blumenfeld, P. C. Billings, J. W. Orf, C. G. Pan, D. K. Palmer, L. A. Snyder
    Pages 45-48

  7. Nonhistone Proteins and Chromosome Structure

    • D. E. Comings, T. A. Okada
    Pages 49-52

  8. The Current Status of Cloning and Nuclear Reprograming in Amphibian Eggs

    • M. A. DiBerardino, N. J. Hoffner
    Pages 53-64

  9. Control of Early Embryonic Development: An Analysis of a Cytoplasmic Component and Its Mode of Action

    • A. J. Brothers
    Pages 65-70

  10. Evidence of the First Genetic Activity Required in Axolotl Development

    • J. Signoret
    Pages 71-74

  11. Genetic Manipulation of the Early Mouse Embryo

    • Karl Illmensee
    Pages 75-86

  12. The Analysis of Cell Differentiation by Hybridization of Somatic Cells

    • M. C. Weiss
    Pages 87-92

  13. Chromosomal Changes Associated with Premalignancy and Cancer

    • J. Cervenka
    Pages 93-101

  14. Chromosomes and Tumor Progression

    • P. C. Nowell
    Pages 102-106

  15. Surface Antigens in Early Embryonic Development

    • R. Kemler, D. Morello, Ch. Babinet, F. Jacob
    Pages 107-111

  16. The Role of Fibronectin in Cellular Behavior

    • R. O. Hynes
    Pages 112-123

  17. Desmin and Intermediate Filaments in Muscle Cells

    • E. Lazarides
    Pages 124-131

  18. The Microtubule Cytoskeleton in Normal and Transformed Cells in Vitro

    • B. R. Brinkley, L. J. Wible, B. B. Asch, D. Medina, M. M. Mace, P. T. Beall et al.
    Pages 132-138

  19. Cytoplasmic Zone Analysis in the Study of the Polysomes of Differentiated Cells

    • J.-E. Edström, U. Lönn
    Pages 139-146

  20. Mechanism of Morphogenetic Tissue Interactions: The Message of Transfilter Experiments

    • L. Saxén
    Pages 147-154
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Keywords

About this book

There is no commonly accepted mechanism to explain differentiation of either normal or neoplastic cells. Despite this fact, the organizers of the 3 rd International Conference on Differentiation recognized that there is much emerging evidence which supports the view that both normal cells and many cancer cells share common differentiative processes. Accordingly, the organizers perceived that clinical scientists and developmental biologists would greatly benefit by together considering differentiation. In that way, developmental biologists would be apprised of recent insights in cancer cell biology and the physician scientist would be updated on events in developmental biology and both would gain new understanding of the cell biology of neoplasia. A specific example may reveal the potential value of developmental biologists interacting with cancer physicians. An example chosen at random suggests that probably any paper included in the symposium volume would serve the purpose. Dr. Stephen Subtelny reviewed recent studies by his laboratory concerning germ cell migration and replication in frog embryos. How might those results interest the cancer scientist? Dr. Subtelny showed that primordial germ cells of a fertile graft will reverse their migratory direction and move into a sterile host. Perhaps in this context it would not be inappropriate to state that the germ cells of the graft metastasized into the host. Germ cells from grafts of a different species will populate the previously sterile host gonad.

Editors and Affiliations

  • Department of Genetics and Cell Biology, University of Minnesota, St. Paul, USA

    Robert G. McKinnell, Martin Blumenfeld, Robert D. Bergad

  • Department of Anatomy, Medical College of Pennsylvania, Philadelphia, USA

    Marie A. DiBerardino

Bibliographic Information

  • Book Title: Differentiation and Neoplasia

  • Editors: Robert G. McKinnell, Marie A. DiBerardino, Martin Blumenfeld, Robert D. Bergad

  • Series Title: Results and Problems in Cell Differentiation

  • DOI: https://doi.org/10.1007/978-3-540-38267-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1980

  • Softcover ISBN: 978-3-662-11561-9Published: 11 January 2013

  • eBook ISBN: 978-3-540-38267-6Published: 09 March 2013

  • Series ISSN: 0080-1844

  • Series E-ISSN: 1861-0412

  • Edition Number: 1

  • Number of Pages: XVI, 312

  • Number of Illustrations: 57 b/w illustrations

  • Topics: Cancer Research, Cell Biology

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