Differentiation and Neoplasia

1. Front Matter

   Pages I-XVI

   PDF

2. Cell Differentiation Yesterday and Today

   • J. Brachet

   Pages 1-7

3. Gene Injections into Amphibian Oocytes

   • D. A. Melton, R. Cortese, E. M. de Robertis, M. F. Trendelenburg, J. B. Gurdon

   Pages 8-14

4. Organization of Transcribed and Nontranscribed Chromatin

   • W. W. Franke, U. Scheer, H. Zentgraf, M. F. Trendelenburg, U. Müller, G. Krohne et al.

   Pages 15-36

5. Visualization of Transcriptional Activity During Xenopus laevis Oogenesis

   • K. Martin, Y. N. Osheim, A. L. Beyer, O. L. Miller Jr.

   Pages 37-44

6. Differential Histone Phosphorylation During Drosophila Development

   • M. Blumenfeld, P. C. Billings, J. W. Orf, C. G. Pan, D. K. Palmer, L. A. Snyder

   Pages 45-48

7. Nonhistone Proteins and Chromosome Structure

   • D. E. Comings, T. A. Okada

   Pages 49-52

8. The Current Status of Cloning and Nuclear Reprograming in Amphibian Eggs

   • M. A. DiBerardino, N. J. Hoffner

   Pages 53-64

9. Control of Early Embryonic Development: An Analysis of a Cytoplasmic Component and Its Mode of Action

   • A. J. Brothers

   Pages 65-70

10. Evidence of the First Genetic Activity Required in Axolotl Development

    • J. Signoret

    Pages 71-74

11. Genetic Manipulation of the Early Mouse Embryo

    • Karl Illmensee

    Pages 75-86

12. The Analysis of Cell Differentiation by Hybridization of Somatic Cells

    • M. C. Weiss

    Pages 87-92

13. Chromosomal Changes Associated with Premalignancy and Cancer

    • J. Cervenka

    Pages 93-101

14. Chromosomes and Tumor Progression

    • P. C. Nowell

    Pages 102-106

15. Surface Antigens in Early Embryonic Development

    • R. Kemler, D. Morello, Ch. Babinet, F. Jacob

    Pages 107-111

16. The Role of Fibronectin in Cellular Behavior

    • R. O. Hynes

    Pages 112-123

17. Desmin and Intermediate Filaments in Muscle Cells

    • E. Lazarides

    Pages 124-131

18. The Microtubule Cytoskeleton in Normal and Transformed Cells in Vitro

    • B. R. Brinkley, L. J. Wible, B. B. Asch, D. Medina, M. M. Mace, P. T. Beall et al.

    Pages 132-138

19. Cytoplasmic Zone Analysis in the Study of the Polysomes of Differentiated Cells

    • J.-E. Edström, U. Lönn

    Pages 139-146

20. Mechanism of Morphogenetic Tissue Interactions: The Message of Transfilter Experiments

    • L. Saxén

    Pages 147-154

There is no commonly accepted mechanism to explain differentiation of either normal or neoplastic cells. Despite this fact, the organizers of the 3 rd International Conference on Differentiation recognized that there is much emerging evidence which supports the view that both normal cells and many cancer cells share common differentiative processes. Accordingly, the organizers perceived that clinical scientists and developmental biologists would greatly benefit by together considering differentiation. In that way, developmental biologists would be apprised of recent insights in cancer cell biology and the physician scientist would be updated on events in developmental biology and both would gain new understanding of the cell biology of neoplasia. A specific example may reveal the potential value of developmental biologists interacting with cancer physicians. An example chosen at random suggests that probably any paper included in the symposium volume would serve the purpose. Dr. Stephen Subtelny reviewed recent studies by his laboratory concerning germ cell migration and replication in frog embryos. How might those results interest the cancer scientist? Dr. Subtelny showed that primordial germ cells of a fertile graft will reverse their migratory direction and move into a sterile host. Perhaps in this context it would not be inappropriate to state that the germ cells of the graft metastasized into the host. Germ cells from grafts of a different species will populate the previously sterile host gonad.

• Cytoplasmic effects
• Krebs
• Neoplasia
• Oncology
• Tumor
• Zelldifferenzierung
• cell biology
• developmental biology
• migration

• Department of Genetics and Cell Biology, University of Minnesota, St. Paul, USA

  Robert G. McKinnell, Martin Blumenfeld, Robert D. Bergad

• Department of Anatomy, Medical College of Pennsylvania, Philadelphia, USA

  Marie A. DiBerardino

Policies and ethics