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The Histone Code and Beyond

New Approaches to Cancer Therapy

  • Conference proceedings
  • © 2006

Overview

Editors:
  1. S. L. Berger

    1. Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, USA

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  2. O. Nakanishi

    1. CRBA Oncology, Nihon Schering, Kobe, Japan

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    You can also search for this editor in PubMed   Google Scholar

  3. B. Haendler

    1. CRBA Oncology, Schering AG, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Latest findings in the field of epigenetics, DNA and histone modifications
  • Biochemical, genetic and structural aspects are presented by top specialists
  • Includes supplementary material: sn.pub/extras

Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 57)

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Table of contents (11 papers)

  1. Front Matter

    Pages I-XIV
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  2. The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development

    • S. Kubicek, G. Schotta, M. Lachner, R. Sengupta, A. Kohlmaier, L. Perez-Burgos et al.
    Pages 1-27

  3. Nucleosome Structure and Function

    • J. V. Chodaparambil, R. S. Edayathumangalam, Y. Bao, Y. -J. Park, K. Luger
    Pages 29-46

  4. The Role of Snf2-Related Proteins in Cancer

    • T. Owen-Hughes
    Pages 47-59

  5. Imitation Switch Complexes

    • J. Mellor
    Pages 61-87

  6. How Is Epigenetic Information on Chromatin Inherited After DNA Replication?

    • Y. Nakatani, H. Tagami, E. Shestakova
    Pages 89-96

  7. Polycomb Silencing Mechanisms and Genomic Programming

    • V. Pirrotta
    Pages 97-113

  8. CpG Island Methylation and Histone Modifications: Biology and Clinical Significance

    • M. Esteller
    Pages 115-126

  9. Histone Post-Translational Modifications Regulate Transcription and Silent Chromatin in Saccharomyces cerevisiae

    • N. C. Tolga Emre, S. L. Berger
    Pages 127-153

  10. Histone Acetylation-Mediated Chromatin Compaction During Mouse Spermatogenesis

    • J. Govin, C. Lestrat, C. Caron, C. Pivot-Pajot, S. Rousseaux, S. Khochbin
    Pages 155-172

  11. Role of Ubiquitin-Like Proteins in Transcriptional Regulation

    • R. T. Hay
    Pages 173-192

  12. Interplay of the SUMO and MAP Kinase Pathways

    • S. -H. Yang, A. D. Sharrocks
    Pages 193-209

  13. Back Matter

    Pages 211-215
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Keywords

About this book

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Editors and Affiliations

  • Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, USA

    S. L. Berger

  • CRBA Oncology, Nihon Schering, Kobe, Japan

    O. Nakanishi

  • CRBA Oncology, Schering AG, Berlin, Germany

    B. Haendler

Bibliographic Information

  • Book Title: The Histone Code and Beyond

  • Book Subtitle: New Approaches to Cancer Therapy

  • Editors: S. L. Berger, O. Nakanishi, B. Haendler

  • Series Title: Ernst Schering Foundation Symposium Proceedings

  • DOI: https://doi.org/10.1007/3-540-37633-X

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2006

  • Hardcover ISBN: 978-3-540-27857-3Published: 22 February 2006

  • Softcover ISBN: 978-3-642-42175-4Published: 27 November 2014

  • eBook ISBN: 978-3-540-37633-0Published: 19 January 2007

  • Series ISSN: 0947-6075

  • Edition Number: 1

  • Number of Pages: XIV, 215

  • Topics: Biochemistry, general, Cell Biology, Oncology

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