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Genome Integrity

Facets and Perspectives

  • Book
  • © 2007

Overview

Editors:
  1. Dirk-Henner Lankenau
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  • First book to give a full overview on genome integrity in different species
  • Spans from microorganisms to humans
  • Addresses the connection between genome integrity and human disease
  • Written by an international panel of experts

Part of the book series: Genome Dynamics and Stability (GENOME, volume 1)

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XII
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  2. Replication

    1. Front Matter

      Pages 1-2
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    2. Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories

      • Richard Egel
      Pages 3-26

    3. Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork

      • Heinz Peter Nasheuer, Helmut Pospiech, Juhani Syväoja
      Pages 27-68

    4. DNA Polymerases and Diseases

      • Kristijan Ramadan, Giovanni Maga, Ulrich Hübscher
      Pages 69-102

  3. Replicative Double-Strand Break Repair

    1. Front Matter

      Pages 103-104
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    2. Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing

      • Christian Rudolph, K. Anke Schürer, Wilfried Kramer
      Pages 105-152

    3. Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution

      • D.-H. Lankenau
      Pages 153-197

  4. Facets of Double-Strand Break Repair

    1. Front Matter

      Pages 199-200
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    2. Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology

      • Karl-Peter Hopfner
      Pages 201-218

    3. Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays

      • Petra Pfeiffer, Steffi Kuhfittig-Kulle, Wolfgang Goedecke
      Pages 219-242

    4. Role of p53 in Double-Strand Break Repair

      • Susanne Andrea Gatz, Lisa Wiesmüller
      Pages 243-266

    5. The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks

      • Anna A. Friedl
      Pages 267-283

  5. DNA Repair and Pleiotropic Interactions

    1. Front Matter

      Pages 285-286
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    2. DNA Base Damage Recognition and Processing

      • Grigory L. Dianov, Sarah L. Allinson
      Pages 287-314

    3. Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity

      • Birgitte B. Olsen, Karsten Niefind, Olaf-Georg Issinger
      Pages 315-342

    4. Role of Human Topoisomerase I in DNA Repair and Apoptosis

      • Kent Søe, Anja Rockstroh, Frank Grosse
      Pages 343-362

    5. Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome

      • Martin Digweed
      Pages 363-380

  6. Radiation and other Genotoxic Stress

    1. Front Matter

      Pages 381-382
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    2. Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress

      • Markus Christmann, Gerhard Fritz, Bernd Kaina
      Pages 383-398
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Keywords

About this book

Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.

Bibliographic Information

  • Book Title: Genome Integrity

  • Book Subtitle: Facets and Perspectives

  • Editors: Dirk-Henner Lankenau

  • Series Title: Genome Dynamics and Stability

  • DOI: https://doi.org/10.1007/b104871

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2007

  • Hardcover ISBN: 978-3-540-37528-9Published: 07 November 2006

  • Softcover ISBN: 978-3-642-07226-0Published: 25 November 2010

  • eBook ISBN: 978-3-540-37531-9Published: 14 October 2006

  • Series ISSN: 1861-3373

  • Series E-ISSN: 1861-3381

  • Edition Number: 1

  • Number of Pages: XI, 496

  • Topics: Cell Biology, Biochemistry, general, Human Genetics

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