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Left-Right Asymmetry in Vertebrate Development

  • Book
  • © 2007

Overview

Authors:
  1. Maria L. López-Gracia

    1. Departamento de Anatomía y Biología Celular, Faculdad de Medicina, Universidad de Cantabria, Santander, Spain

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  2. Marian Ros

    1. Departamento de Anatomía y Biología Celular, Faculdad de Medicina, Universidad de Cantabria, Santander, Spain

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Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 188)

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Table of contents (6 chapters)

  1. Front Matter

    Pages I-XI
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  2. Introduction

    Pages 1-13

  3. Establishment of Left-Right Asymmetry

    Pages 13-35

  4. Signaling Pathways with a Predominant Role in Left-Right Patterning

    Pages 35-44

  5. Mouse Models of Laterality

    Pages 44-70

  6. Genetics of Human Alterations of Organ Situs

    Pages 70-79

  7. Concluding Remarks

    Pages 80-95

  8. Back Matter

    Pages 96-126
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Keywords

About this book

Externally the vertebrate body plan presents a bilateral symmetry in relation to the midline. However, inside the body the distribution of the visceral organs follows a very particular pattern that is not symmetrical in relation to the midline. The last 10 years have seen remarkable advances in our understanding of how the internal asymmetries typical of the vertebrate body are established and controlled. The use of different development models has permitted to uncover fascinating ways of creating asymmetry, like the activity of the nodal cilia. A host of studies has also unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.

Authors and Affiliations

  • Departamento de Anatomía y Biología Celular, Faculdad de Medicina, Universidad de Cantabria, Santander, Spain

    Maria L. López-Gracia, Marian Ros

Bibliographic Information

  • Book Title: Left-Right Asymmetry in Vertebrate Development

  • Authors: Maria L. López-Gracia, Marian Ros

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-540-36348-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2007

  • Softcover ISBN: 978-3-540-36347-7Published: 11 December 2006

  • eBook ISBN: 978-3-540-36348-4Published: 03 February 2007

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: XII, 126

  • Number of Illustrations: 3 b/w illustrations, 13 illustrations in colour

  • Topics: Human Physiology

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