Selective Estrogen Receptor Modulators

1. Front Matter

   Pages I-XVII

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2. Basic Area

   1. Front Matter

      Pages 1-1

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   2. Molecular Mechanisms of Estrogen Action in Target Tissues

      • B. Nicolás Díaz Chico, Domingo Navarro Bosch, Juan C. Díaz Chico, Eduardo Escrich Escriche

      Pages 2-47

   3. Clinical Pharmacology of Selective Estrogen Receptor Modulators (SERMs)

      • Fernando Marín, Ma Carmen Barbancho

      Pages 49-69

   4. Action of Selective Estrogen Receptor Modulators (SERMs) Through the Classical Mechanism of Estrogen Action

      • Fernando Marín, Ma Carmen Barbancho

      Pages 71-77

   5. Cellular and Molecular Basis for Acute Nongenomically Mediated Actions of SERMs

      • Mario Díaz, Jorge Marrero-Alonso, Benito García Marrero, Raquel Marín, Tomás Gomez, Rafael Alonso

      Pages 79-102

   6. The Hypothalamus-Pituitary-Ovarian Axis as a Model System for the Study of SERM Effects: An Overview of Experimental and Clinical Studies

      • R. Alonso, F. Marín, M. González, P. Guelmes, C. Bellido, G. Hernández et al.

      Pages 103-139

   7. Pure Antiestrogens

      • Carlos Hermenegildo

      Pages 141-157

3. Clinical Area

   1. Front Matter

      Pages 159-159

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   2. Physiological Regulation of Bone Metabolism and Estrogen Agonism

      • Miguel Angel García-Pérez

      Pages 161-186

   3. The Role of SERMs in the Treatment of Osteoporosis

      • Adolfo Díez-Pérez, José Luis Dueñas-Díez

      Pages 187-206

   4. Cardiovascular Disease and SERMs

      • Antonio Cano

      Pages 207-238

   5. SERMs and the Breast

      • Joaquim Calaf i Alsina, Antonio Cano Sanchez

      Pages 239-270

   6. Endometrial Effects of SERMs

      • Santiago Palacios

      Pages 271-290

   7. Benign Gynecological Diseases and SERMs

      • Stefano Palomba, Fulvio Zullo

      Pages 291-311

   8. Other Clinical Effects of SERMs

      • P. Acién, F. Quereda, M. I. Acién

      Pages 313-332

   9. The Role of SERMs in the Management of Postmenopausal Women

      • Joaquim Calaf i Alsina

      Pages 333-349

4. Back Matter

   Pages 351-357

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The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.

• Estrogen Receptors
• Mechanisms of Action
• Osteoporosis prevetion
• Osteorporosis treatment
• SERMS
• estrogen action
• estrogen receptor

From the reviews of the first edition:

"Sanchez and colleagues have assembled a timely addition to the clinician’s library. Their book is an up-to-date synthesis of the basic mechanisms of action of estrogen and SERMs with a comprehensive analysis of receptor-mediated and non-receptor mediated events in target tissue. The sections on new SERMs and the clinical endocrinology of SERMs are very useful and will remain so for some time. The choice of basic and clinical topics makes for interesting reading. … Overall, the book is well written and easy to read." (V. Craig Jordan, The New England Journal of Medicine, January, 2007)

• Department of Pediatrics Obstetrics and Gynecology School of Medicine, University of Valencia, Valencia, Spain

  Antonio Cano Sanchez

• Servei d’Obstetricia i Ginecologia, Hospital de la Santa Creu i Sant Pau, Barcelona

  Joaquim Calaf i Alsina

• Department of Obstetrics and Gynaecology, Hospital Universitario Virgen Macarena, School of Medicine University of Sevilla, Sevilla, Spain

  José-Luis Dueñas-Díez

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