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Stem Cells

  • Book
  • © 2006

Overview

Editors:
  1. Anna M. Wobus

    1. In Vitro Differentiation Group, Dept. of Cytogenetics, Leibnitz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Kenneth R. Boheler

    1. Laboratory of Cardiovascular Science, Gerontology Research Program, National Institute on Aging, NIH, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 174)

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Table of contents (16 chapters)

  1. Front Matter

    Pages I-XI
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  2. Factors Involved in Self-Renewal and Pluripotency of Embryonic Stem Cells

    • H. Darr, N. Benvenisty
    Pages 1-19

  3. Embryonic Stem Cell-Derived Embryoid Bodies: An In Vitro Model of Eutherian Pregastrulation Development and Early Gastrulation

    • G. Weitzer
    Pages 21-51

  4. Embryonic Stem Cells: A Novel Tool for the Study of Antiangiogenesis and Tumor-Induced Angiogenesis

    • M. Wartenberg, F. Dönmez, P. Budde, H. Sauer
    Pages 53-71

  5. Cardiac Repair by Embryonic Stem-Derived Cells

    • M. Rubart, L.J. Field
    Pages 73-100

  6. Cardiomyocytes from Human Embryonic Stem Cells

    • R. Passier, C. Denning, C. Mummery
    Pages 101-122

  7. Autocrine and Intracrine Signaling for Cardiogenesis in Embryonic Stem Cells: A Clue for the Development of Novel Differentiating Agents

    • C. Ventura, A. Branzi
    Pages 123-146

  8. Therapeutic Potential of Stem Cells in Diabetes

    • E. Roche, R. Enseñat-Waser, J.A. Reig, J. Jones, T. León-Quinto, B. Soria
    Pages 147-167

  9. The Stem Cell Continuum: A New Model of Stem Cell Regulation

    • P.J. Quesenberry, G.A. Colvin, M.S. Dooner
    Pages 169-183

  10. Markers of Adult Tissue-Based Stem Cells

    • M.R. Alison, M. Brittan, M.J. Lovell, N.A. Wright
    Pages 185-227

  11. Designer Cytokines for Human Haematopoietic Progenitor Cell Expansion: Impact for Tissue Regeneration

    • S. Rose-John
    Pages 229-247

  12. Mesenchymal Stem Cells: Isolation, In Vitro Expansion and Characterization

    • N. Beyer Nardi, L. da Silva Meirelles
    Pages 249-282

  13. Neovascularization and Cardiac Repair by Bone Marrow-Derived Stem Cells

    • C. Badorff, S. Dimmeler
    Pages 283-298

  14. The Potential Use of Myogenic Stem Cells in Regenerative Medicine

    • G. Grenier, M.A. Rudnicki
    Pages 299-317

  15. Neural Stem Cells: On Where They Hide, in Which Disguise, and How We May Lure Them Out

    • B. Berninger, M.A. Hack, M. Götz
    Pages 319-360

  16. Cell Transplantation for Patients with Parkinson’s Disease

    • G. Paul
    Pages 361-388

  17. Postmodern Biology: (Adult) (Stem) Cells Are Plastic, Stochastic, Complex, and Uncertain

    • N.D. Theise, R. Harris
    Pages 389-408

  18. Back Matter

    Pages 409-414
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About this book

Signi?cant advances in stem cell research and their potentials for therap- tic applications have attracted the attention of the scienti?c community and captured the imagination of society as a whole. Not so long ago, the study of most stem cells, other than those that regenerated the haematopoietic system, was rather obscure and limited to a relatively small number of researchers and laboratories. The uproar over stem cells really began in 1998 with the s- cessful derivation of pluripotent human embryonic stem (ES) cells by James Thomson and co-workers. This breakthrough and the subsequent generation of specialized human cells in vitro led to a paradigm shift within the sci- ti?c community, which transformed this specialized endeavour from a topic of scienti?c interest to a line of investigation with the potential to generate cells - pable of treating serious ailments, including diabetes, cardiovascular diseases and neurodegenerative disorders. Thus the dawn of regenerative medicine has spawned from the somewhat esoteric study of stem cells. Since 1998, extensive research endeavours have been devoted to the study of both embryonic and adult stem cells. Early reports suggested that adult stem cells had a higher plasticity than previously believed, perhaps even comparable with that demonstrated by embryonic stem cells, but several observations of the so-called transdifferentiation capacity and plasticity of adult stem cells have not been repeated. These reports, however, encouraged on-going debates about the capacity of adult versus embryonic stem cells and their potential use in regenerative medicine.

Editors and Affiliations

  • In Vitro Differentiation Group, Dept. of Cytogenetics, Leibnitz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany

    Anna M. Wobus

  • Laboratory of Cardiovascular Science, Gerontology Research Program, National Institute on Aging, NIH, Baltimore, USA

    Kenneth R. Boheler

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