Drug Discovery and Evaluation: Pharmacological Assays

Now expanded and updated to include molecular biology and genetic engineering techniques! The 2nd edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic respiratory, renal and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. The enclosed and fully searchable CD-ROM allows easy identification of specific tests. An appendix with up-to-date guidelines and legal regulations for animal experiments in various countries will help the reader to plan experiments more effectively.

• Arzneimittel
• Arzneimittelwirkungen
• Pharmakologie
• Toxikologie
• Wirkstoffe
• Wirkstoffforschung
• assays
• drug action
• drugs
• pharmacological tests
• toxicology
• Arzneimittelwirkung
• biology
• drug
• drug discovery
• molecular biology
• pharmaceutical
• pharmacology
• research

From the reviews of the second edition:

"Pharmacological studies are a pivotal but sometimes neglected area … . Failure to evaluate your candidate compound in appropriate models will greatly reduce your chances of success … . This excellent reference book will assist you in avoiding this fate. … Although the update has increased the book from around 750 to 1400 pages, it is still indexed in a clear, concise way making access to each assay easy. … I would thoroughly recommend this book. … it is a well-worth, long term investment." (Paul Baldrick, British Toxicology Society Newsletter, Issue 20, 2002)

"The second edition of ‘Drug Discovery and Evaluation’ presents an expanded and updated version of one of the classic reference handbooks on pharmacological assays. … Each assay description is sufficiently outlined and equipped with outstanding literature references. … A newly included CD-ROM provides easy identification of tests, guidelines and even legal regulations for animal experiments. … This comprehensive classical reference handbook mainly addresses the needs of pharmacological institutes and research groups working in this area." (Dr. Jürg Gertsch, BioWorld, Issue 2, 2003)

• Johann Wolfgang Goethe-Universität, Frankfurt, Germany

  H. Gerhard Vogel

• Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, USA

  Wolfgang H. Vogel

• Aventis Deutschland GmbH, Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt, Germany

  Bernward A. Schölkens, Jürgen Sandow

• Institut für Genetik, Avenfis Deutschland GmbH, Ludwig Maximilian-Universität München, München, Germany

  Günter Müller

• Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada

  Wolfgang F. Vogel

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