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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

  • Reference work
  • © 2006

Overview

Editors:
  1. H. Gerhard Vogel

    1. Johann-Wolfgang-Goethe-Universit¤t, Frankfurt am Main, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Franz Jakob Hock

    1. Dieburg, Germany

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  3. Jochen Maas

    1. Aventis Pharma Deutschland GmbH, Frankfurt, Germany

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  4. Dieter Mayer

    1. Idstein, Germany

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  • A landmark in the continuously changing world of drugs
  • Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process
  • Of use for government institutions and committees working on official guidelines for drug evaluation worldwide

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Table of contents (48 entries)

  1. Front Matter

    Pages i-xxxi
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  2. Safety Pharmacology

    1. Front Matter

      Pages 1-1
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    2. Introduction to Safety Pharmacology

      • Franz J. Hock
      Pages 3-3

    3. Status of Safety Pharmacology and Present Guidelines

      • Franz J. Hock
      Pages 5-13

    4. Central Nervous System (CNS) Safety Pharmacology Studies

      • Roger D. Porsolt, Vincent Castagné, Niklaus Dürmüller, Martine Lemaire, Paul Moser, Sylvain Roux et al.
      Pages 15-60

    5. Methods in Cardiovascular Safety Pharmacology

      • Brian D. Guth
      Pages 61-94

    6. Safety Pharmacology of Drugs for the Urinary Tract

      • Susan G. Emeigh Hart
      Pages 95-140

    7. Respiratory Function Assays in Safety Pharmacology

      • Dennis J. Murphy
      Pages 141-149

    8. Metabolism Pharmacology

      • Andreas W. Herling
      Pages 151-193

    9. Peripheral Nervous System

      • H. Gerhard Vogel
      Pages 195-209

    10. Safety of Intravenous and Inhalation Anesthetics

      • H. Gerhard Vogel
      Pages 211-217

    11. Side Effects of Central Analgesic Drugs

      • Charles P. France
      Pages 219-231

    12. Safety Pharmacology of Antiinflammatory Drugs

      • H. Gerhard Vogel
      Pages 233-242

    13. Safety Pharmacology of Drugs with Osteoarthritis-Related Activity

      • Ruth Raiss
      Pages 243-254

    14. Safety Pharmacology of Blood Constituents

      • Shaker A. Mousa
      Pages 255-318

    15. Ocular Toxicity Tests

      • Beth L. Schultz
      Pages 319-326

    16. Assays in Endocrine Safety Pharmacology

      • Jürgen Sandow
      Pages 327-363

    17. Safety Assays in Skin Pharmacology

      • Marina Goldovsky, Hongbo Zhai, Emi Dika, Howard I. Maibach
      Pages 365-383

    18. Magnetic Resonance Imaging in Pharmaceutical Safety Assessment

      • Paul Hockings
      Pages 385-393

  3. Safety Pharmacokinetics

    1. Front Matter

      Pages 395-295
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Keywords

Editors and Affiliations

  • Johann-Wolfgang-Goethe-Universit¤t, Frankfurt am Main, Germany

    H. Gerhard Vogel

  • Dieburg, Germany

    Franz Jakob Hock

  • Aventis Pharma Deutschland GmbH, Frankfurt, Germany

    Jochen Maas

  • Idstein, Germany

    Dieter Mayer

Bibliographic Information

  • Book Title: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

  • Editors: H. Gerhard Vogel, Franz Jakob Hock, Jochen Maas, Dieter Mayer

  • DOI: https://doi.org/10.1007/3-540-29804-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Reference Module Biomedical and Life Sciences

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2006

  • eBook ISBN: 978-3-540-29804-5Published: 21 September 2006

  • Edition Number: 1

  • Number of Pages: XXXI, 889

  • Number of Illustrations: 131 b/w illustrations

  • Topics: Pharmacology/Toxicology

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