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Regulation of Sertoli Cell and Germ Cell Differentiation

  • Book
  • © 2005

Overview

Authors:
  1. Ralph Brehm

    1. Institut für Veterinär-Anatomie, Histologie und Embryologie, Justus-Liebig Universtät, Giessen, Germany

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  2. Klaus Steger

    1. Klinik und Poliklinik für Urologie und Kinderurologie, Justus-Liebig Universtät, Giessen, Germany

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Editors:
  1. F. F. Beck

    1. Melbourne

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  2. B. Christ

    1. Freiburg

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  3. F. Clascá

    1. Madrid

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  4. D. E. Haines

    1. Jackson

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  5. H.-W. Korf

    1. Frankfurt

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  6. W. Kummer

    1. Giessen

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  7. E. Marani

    1. Leiden

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  8. R. Putz

    1. München

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  9. Y. Sano

    1. Kyoto

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  10. T.H. Schiebler

    1. Würzburg

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  11. K. Zilles

    1. Düsseldorf

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Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 181)

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Table of contents (5 chapters)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. Spermatogenesis

    • Klaus Steger
    Pages 1-7

  3. The Sertoli Cell

    • Ralph Brehm
    Pages 7-36

  4. The Differentiation of Male Germ Cells

    • Klaus Steger
    Pages 36-45

  5. Idiopathic Male Infertility: Impaired Histone-to-Protamine Exchange?

    • Klaus Steger
    Pages 45-49

  6. Carcinoma In Situ of the Testis and Testicular Germ Cell Tumour: Impaired Intercellular Communication Due to Altered Sertoli Cell Differentiation?

    • Ralph Brehm
    Pages 49-70

  7. Back Matter

    Pages 71-107
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Keywords

About this book

Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.

Authors, Editors and Affiliations

  • Melbourne

    F. F. Beck

  • Freiburg

    B. Christ

  • Madrid

    F. Clascá

  • Jackson

    D. E. Haines

  • Frankfurt

    H.-W. Korf

  • Giessen

    W. Kummer

  • Leiden

    E. Marani

  • München

    R. Putz

  • Kyoto

    Y. Sano

  • Würzburg

    T.H. Schiebler

  • Düsseldorf

    K. Zilles

  • Institut für Veterinär-Anatomie, Histologie und Embryologie, Justus-Liebig Universtät, Giessen, Germany

    Ralph Brehm

  • Klinik und Poliklinik für Urologie und Kinderurologie, Justus-Liebig Universtät, Giessen, Germany

    Klaus Steger

Bibliographic Information

  • Book Title: Regulation of Sertoli Cell and Germ Cell Differentiation

  • Authors: Ralph Brehm, Klaus Steger

  • Editors: F. F. Beck, B. Christ, F. Clascá, D. E. Haines, H.-W. Korf, W. Kummer, E. Marani, R. Putz, Y. Sano, T.H. Schiebler, … K. Zilles

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/3-540-29446-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2005

  • Softcover ISBN: 978-3-540-25750-9Published: 16 September 2005

  • eBook ISBN: 978-3-540-29446-7Published: 12 December 2005

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: X, 95

  • Number of Illustrations: 23 b/w illustrations, 3 illustrations in colour

  • Topics: Biomedicine general

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