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Biologics in General Medicine

  • Book
  • © 2007

Overview

Editors:
  1. Wolf-Henning Boehncke

    1. Department of Dermatology, Clinic of the Johann-Wolfgang-Goethe-University, Frankfurt

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  2. Heinfried H. Radeke

    1. Dr.-Hans-Schleussner-Foundation Immune Pharmacology pharmazentrum frankfurt, Bldg. 75, Room 103, Johann-Wolfgang-Goethe-University, Frankfurt

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First comprehensive book on the new drug generation of biologicals

  • Contains all biologicals presently approved for clinical application

  • Covers all aspects from the biotechnological production processes to the clinical applications

  • Includes safety and regulatory aspects

  • Includes supplementary material: sn.pub/extras

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-XVIII
    Download chapter PDF

  2. Introduction: Definition and Classification of Biologics

    1. Introduction: Definition and Classification of Biologics

      • W. -H. Boehncke, H. H. Radeke
      Pages 1-2

  3. Development and Pre-clinical Pharmacology of Biologics

    1. Front Matter

      Pages 3-3
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    2. Infliximab: From the Idea to the Product

      • M. Wiekowski, Ch. E. Antoni
      Pages 5-13

    3. Adalimumab

      • J. Salfeld, H. Kupper
      Pages 14-31

    4. Etanercept

      • Ch. T. Molta
      Pages 32-41

    5. Efalizumab: Antibody Characteristics, Mode of Action and Preclinical Development

      • S. Jahn, K. Schmitt-Rau
      Pages 42-49

    6. Monoclonal Antibody Targeted Radiation Cancer Therapy

      • L. M. M. Keller, C. A. Boswell, D. E. Milenic, E. D. Brady, M. W. Brechbiel
      Pages 50-58

    7. The Production of Biopharmaceuticals

      • B. Hughes, L. E. Hann
      Pages 59-66

  4. Disease-Specific Applications and Clinical Trials

    1. Front Matter

      Pages 67-67
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    2. Treating Autoimmune Bullous Skin Disorders with Biologics

      • R. Eming, A. Niedermeier, M. Pfütze, A. Jacobi, M. Hertl
      Pages 69-80

    3. Biologics in Psoriasis

      • W. A. Myers, W. -H. Boehncke, A. B. Gottlieb
      Pages 81-96

    4. Biologic Agents in Psoriatic Arthritis

      • P. Mease
      Pages 97-110

    5. Biologic Therapies for Rheumatoid Arthritis Targeting TNF-α and IL-1

      • P. C. Taylor
      Pages 111-123

    6. Biologics in Crohn’s Disease and Ulcerative Colitis: Focus on Tumor Necrosis Factor Antagonists

      • J. Salfeld, P. Rutgeerts
      Pages 124-140

    7. Multiple Sclerosis: New Immunobiologics

      • R. Gold, R. Hohlfeld
      Pages 141-146

    8. Biologics in Cutaneous Lymphoma

      • M. Beyer, Ch. Assaf, W. Sterry
      Pages 147-152

    9. Biologics in Targeted Cancer Therapy

      • D. Schrama, J. C. Becker
      Pages 153-165

  5. Safety and Perspectives

    1. Front Matter

      Pages 167-167
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    2. Safety Aspects of Biologics: Lessons Learnt from Monoclonal Antibodies

      • C. K. Schneider, J. Löwer
      Pages 169-174
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Keywords

About this book

The idea for this book was born during the symposium on biologics organized by ZAFES (Center for Drug Research, Development and Safety at the University of Frankfurt am Main) in September 2005. Highly distinguished researchers special- ing in the field of biologics had gathered together to exchange information on this relatively new subject. Realizing that this symposium was one of the few sources of condensed information on biologics, it became obvious that we had to create a means of informing an interested wider circle of scientists and especially general c- nicians. Therefore, the editors of this book suggested to the researchers at the symposium andalsotoprominent scientists andcliniciansinvolvedinthe developmentand application of biologics as their major field of interest the idea of assembling this compendium. We received an overwhelmingly positive response – thankfully also from the publisher – most being more than willing to support this innovative project with highly relevant chapters on the latest state of the art. As we were eager to fill the information gap with up-to-date knowledge, the project had to be finished within the shortest time possible. To all experienced with editing this was obviously a ch- lengeand we areverythankfultoall thecontributorsthatour timeline hadtobe extended by only a few months. This book represents a collection of the most recent knowledge on biologics written by people who have been active in the field for many years. Wolf-Henning Boehncke Heinfried H. Radeke Contents 1 Introduction: Definition and Classification of Biologics W. -H. Boehncke, H. H. Radeke . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Editors and Affiliations

  • Department of Dermatology, Clinic of the Johann-Wolfgang-Goethe-University, Frankfurt

    Wolf-Henning Boehncke

  • Dr.-Hans-Schleussner-Foundation Immune Pharmacology pharmazentrum frankfurt, Bldg. 75, Room 103, Johann-Wolfgang-Goethe-University, Frankfurt

    Heinfried H. Radeke

About the editors

Wolf-Henning Boehncke is a scholar of the German Scholarship Foundation. His research work has been supported by continuous funding from the German Research Foundation (DFG). He was awarded numerous prestigious prizes including the Galenus-von Pergamon Prize. Currently, he is head of the Allergy/Immunology Section at the Center for Dermatology at Frankfurt University. He is a member of numerous national and international boards involved in setting up guidelines for the clinical use of biologicals.

Heinfried H. Radeke is holding the Dr.-Schleussner-Foundation of Immune Pharmacology professorship. His research work has been supported by continuous funding from the German Research Foundation (DFG). His specialization is in pharmacology, clinical pharmacology and immunology. His numerous publications reflect the intensive research he has been doing for the past 15 years in the fields of chronic inflammation, transplantation and immune pharmacology. He is actively involved in the establishment of the new B.Sc./M.Sc. studies in Molecular Medicine at Goethe University Frankfurt. He is also involved in the development of the curricula and the lecture courses of the recently established graduate college "Biologicals" (GK1172) at Goethe University Frankfurt.

Bibliographic Information

  • Book Title: Biologics in General Medicine

  • Editors: Wolf-Henning Boehncke, Heinfried H. Radeke

  • DOI: https://doi.org/10.1007/978-3-540-29018-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2007

  • Hardcover ISBN: 978-3-540-29017-9Published: 08 May 2007

  • Softcover ISBN: 978-3-642-43567-6Published: 13 December 2014

  • eBook ISBN: 978-3-540-29018-6Published: 09 August 2007

  • Edition Number: 1

  • Number of Pages: XVIII, 190

  • Topics: Dermatology, Immunology, Allergology, Gastroenterology, Rheumatology

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