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RNA Towards Medicine

  • Book
  • © 2006

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Editors:
  1. Volker Erdmann

    1. Institute of Chemistry/Biochemistry, Free University Berlin, Berlin, Germany

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  2. Jan Barciszewski

    1. Institute of Bioorganic Chemistry, Polish Academy of Scienes, Poznan, Poland

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    You can also search for this editor in PubMed   Google Scholar

  3. Jürgen Brosius

    1. Institute of Experimental Pathology, Molecular Neurobiology (ZMBE), University of Münster, Münster, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 173)

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Table of contents (23 chapters)

  1. Front Matter

    Pages I-XI
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  2. Why RNA and DNA Have Different Structures

    • A. Rich
    Pages 1-8

  3. Regulatory RNAs as Mediators of Virulence Gene Expression in Bacteria

    • T. Geissmann, M. Possedko, E. Huntzinger, P. Fechter, C. Ehresmann, P. Romby
    Pages 9-43

  4. Regulatory RNAs in Mammals

    • M. Szymański, J. Barciszewski
    Pages 45-72

  5. Aminoglycoside Interactions with RNAs and Nucleases

    • L.A. Kirsebom, A. Virtanen, N.E. Mikkelsen
    Pages 73-96

  6. High-Throughput RNA Interference in Functional Genomics

    • M. Janitz, D. Vanhecke, H. Lehrach
    Pages 97-104

  7. Antiviral Applications of RNAi

    • K.V. Morris, J.J. Rossi
    Pages 105-116

  8. RNA Interference: Its Use as Antiviral Therapy

    • J. Haasnoot, B. Berkhout
    Pages 117-150

  9. Gene Silencing of Virus Replication by RNA Interference

    • N. Miyano-Kurosaki, H. Takaku
    Pages 151-171

  10. Progress in the Development of Nucleic Acid Therapeutics

    • A. Kalota, V.R. Dondeti, A.M. Gewirtz
    Pages 173-196

  11. Screening and Determination of Gene Function Using Randomized Ribozyme and siRNA Libraries

    • S. Matsumoto, H. Akashi, K. Taira
    Pages 197-221

  12. Ribozymes and siRNAs: From Structure to Preclinical Applications

    • M. Sioud
    Pages 223-242

  13. Strategies to Identify Potential Therapeutic Target Sites in RNA

    • M. Lützelberger, J. Kjems
    Pages 243-259

  14. Oligonucleotide-Based Antiviral Strategies

    • S. Schubert, J. Kurreck
    Pages 261-287

  15. Gene-Expressed RNA as a Therapeutic: Issues to Consider, Using Ribozymes and Small Hairpin RNA as Specific Examples

    • G.C. Fanning, G. Symonds
    Pages 289-303

  16. RNA Aptamers: From Basic Science Towards Therapy

    • H. Ulrich
    Pages 305-326

  17. RNA Aptamers Directed Against Oligosaccharides

    • M. Sprinzl, M. Milovnikova, C.S. Voertler
    Pages 327-340

  18. Aptamer-Based Biosensors: Biomedical Applications

    • A.K. Deisingh
    Pages 341-357

  19. Application of Aptamers in Therapeutics and for Small-Molecule Detection

    • M. Menger, J. Glökler, M. Rimmele
    Pages 359-373

  20. RNA Aptamers as Potential Pharmaceuticals Against Infections with African Trypanosomes

    • H.U. Göringer, M. Homann, M. Zacharias, A. Adler
    Pages 375-393
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Keywords

About this book

Developments over the past few years have revealed the remarkable versatility of RNA in any compartment of the cell, tasks that had been thought to be exclusively in the realm of proteins and even beyond. The chapters in this book written by leading investigators in the field provide insight into various promising avenues where RNA and nucleic acid derivatives including antisense RNAs, such as siRNA, miRNAs, amplification/selection (SELEX) generated aptamers as well as ribozymes are at the threshold of impacting medicine.

Editors and Affiliations

  • Institute of Chemistry/Biochemistry, Free University Berlin, Berlin, Germany

    Volker Erdmann

  • Institute of Bioorganic Chemistry, Polish Academy of Scienes, Poznan, Poland

    Jan Barciszewski

  • Institute of Experimental Pathology, Molecular Neurobiology (ZMBE), University of Münster, Münster, Germany

    Jürgen Brosius

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