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Animal Models of T Cell-Mediated Skin Diseases

  • Conference proceedings
  • © 2005

Overview

Editors:
  1. T. Zollner

    1. Corporate Research Business Area Dermatology, Schering AG, Berlin, Germany

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  2. H. Renz

    1. Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps-University, Marburg, Germany

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  3. K. Asadullah

    1. Corporate Research Business Area Dermatology, Schering AG, Berlin, Germany

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Part of the book series: Ernst Schering Foundation Symposium Proceedings (SCHERING FOUND, volume 50)

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Table of contents (16 papers)

  1. Front Matter

    Pages I-XIII
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  2. Making Gene-Modified Mice

    • M. Pasparakis
    Pages 1-26

  3. High-Throughput Gene Knockouts and Phenotyping in Mice

    • M. W. Moore
    Pages 27-44

  4. Modelling Gene-Environment Interactions in Th1- and Th2-Dominated Diseases of Laboratory Animals

    • G. A. W. Rook, R. Martinelli, L. Rosa Brunet
    Pages 45-68

  5. Animal Models of Experimental Asthma

    • M. Wegmann, H. Renz
    Pages 69-87

  6. Models of Rheumatoid Arthritis

    • R. O. Williams
    Pages 89-117

  7. Animal Models of Inflammatory Bowel Diseases

    • M. F. Neurath
    Pages 119-132

  8. Murine Models of Atopic Dermatitis

    • T. Brzoska, T. A. Luger
    Pages 133-166

  9. Epicutaneous Sensitization with Allergens as an Atopic Dermatitis Model

    • H. Alenius
    Pages 167-174

  10. T-Cell Receptor Transgenic Models of Inflammatory Disorders: Relevance for Atopic Dermatitis?

    • U. Niesner, F. Hardung, A. Scheffold, A. Radbruch
    Pages 175-191

  11. What Must a Model Display for Proof as a Model of Psoriasis?

    • W. Sterry, J. Foerster
    Pages 193-201

  12. From Classical Mouse Models of Psoriasis to a Spontaneous Xenograft Model Featuring Use of AGR Mice

    • F. O. Nestle, B. J. Nickoloff
    Pages 203-212

  13. The Psoriasis SCID Mouse Model: A Tool for Drug Discovery?

    • W. -H. Boehncke
    Pages 213-234

  14. Pro- and Anti-inflammatory Effects of IL-4: From Studies in Mice to Therapy of Autoimmune Diseases in Humans

    • T. Biedermann, M. Röcken
    Pages 235-242

  15. What Must a Model Display for Proof as a Model of Contact Dermatitis?

    • C. Hauser
    Pages 243-253

  16. Acute and Chronic Models of Allergic Contact Dermatitis: Advantages and Limitations

    • T. M. Zollner, F. H. Igney, K. Asadullah
    Pages 255-275

  17. Transgenic Mice Expressing IFN-γ in the Epidermis Are a Model of Inflammatory Skin Disease and Systemic Lupus Erythematosus

    • F. M. Watt
    Pages 277-291

  18. Back Matter

    Pages 293-296
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Keywords

About this book

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

Editors and Affiliations

  • Corporate Research Business Area Dermatology, Schering AG, Berlin, Germany

    T. Zollner, K. Asadullah

  • Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps-University, Marburg, Germany

    H. Renz

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