Oncogenes and Growth Control

1. Front Matter

   Pages I-XXIII

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2. Introduction

   1. Introduction

      • Patricia Kahn, Thomas Graf

      Pages 1-5

3. Growth Factors and Proto-Oncogenes in Development and Differentiation

   1. Front Matter

      Pages 7-8

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   2. The Expression of Growth Factors and Growth Factor Receptors During Mouse Embryogenesis

      • Aya Jakobovits

      Pages 9-17

   3. A Role for Proto-Oncogenes in Differentiation?

      • Erwin F. Wagner, Rolf Müller

      Pages 18-26

   4. Tissue-Specific Expression and Possible Functions of pp60^c-src

      • Larry R. Rohrschneider

      Pages 27-31

4. Growth Factors, Receptors, and Related Oncogenes

   1. Front Matter

      Pages 33-34

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   2. The Granulocyte-Macrophage Colony-Stimulating Factors

      • Nicholas M. Gough

      Pages 35-42

   3. Role of PDGF-Like Growth Factors in Autocrine Stimulation of Growth of Normal and Transformed Cells

      • Carl-Henrik Heldin, Bengt Westermark

      Pages 43-50

   4. Transforming Growth Factor-β

      • Harold L. Moses, Edward B. Leof

      Pages 51-57

   5. Transforming Growth Factor-α

      • Rik Derynck

      Pages 58-64

   6. The Physiology of Epidermal Growth Factor

      • Graham Carpenter, Linda Goodman, Lynn Shaver

      Pages 65-69

   7. Structural Relationships Between Growth Factor Precursors and Cell Surface Receptors

      • Suzanne Pfeffer, Axel Ullrich

      Pages 70-76

   8. Regulation of Cell Growth by the EGF Receptor

      • Joseph Schlessinger

      Pages 77-84

   9. Mutational Analysis of v-erbB Oncogene Function

      • Hartmut Beug, Michael J. Hayman, Björn Vennström

      Pages 85-92

   10. The c-fms Proto-Oncogene and the CSF-1 Receptor

       • Charles J. Sherr, E. Richard Stanley

       Pages 93-99

   11. Activation of the c-src Gene

       • Hidesaburo Hanafusa

       Pages 100-105

   12. Normal and Transforming N-Terminal Variants of c-abl

       • Yinon Ben-Neriah, David Baltimore

       Pages 106-114

   13. Transformation by the v-abl Oncogene

       • Angelika Gebhardt, J. Gordon Foulkes

       Pages 115-120

   14. mos

       • Donald G. Blair

       Pages 121-127

How is growth controlled in normal cells? How are the growth control mechanisms perturbed in cancer cells? This book provides an up-to-date description of research aimed at resolving these questions. It is organized into four sections, each containing a series of short reviews written by experts in the field. The general headings are: growth factors, receptors, and related oncogenes: transduction of mitogenic signals and ras oncogenes; nuclear oncogenes and regulation of gene expression; and multiple steps involved in malignant transformation. The articles emphasize concepts rather than detailed facts and are intended not only for specialists in the field but also for interested readers, such as physicians and advanced students, who wish to stay abreast of developments in one of the most exciting fields in current biomedical research.

• ATP
• Activation
• Colon
• DNA
• Interleukin-2
• Viruses
• gene expression
• interferon
• regulation
• transcription
• tumorigenesis

• European Molecular Biology Laboratory, Heidelberg, Germany

  Patricia Kahn, Thomas Graf

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