Cancer Risks

1. Front Matter

   Pages I-XIII

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2. General Aspects

   1. Front Matter

      Pages 1-1

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   2. Genetic Predisposition for Cancer Risks in Man

      • D. G. Harnden

      Pages 3-13

   3. The Role of Epidemiology in the Detection and Reduction of Cancer Risks

      • R. Doll

      Pages 14-23

3. Back Matter

   Pages 24-24

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4. Chemical Carcinogens: Risk Assessment

   1. Front Matter

      Pages 25-25

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   2. Assessment of Cancer Risk from Chemicals

      • D. Henschler

      Pages 27-32

   3. Validity of Short-Term Tests to Detect Carcinogenic Chemicals

      • H. Greim, U. Andrae, W. Göggelmann, L. Schwarz, K. H. Summer

      Pages 33-46

   4. Preneoplastic Lesions as Indicators of the Carcinogenic Risk Caused by Chemicals

      • P. Bannasch, H. Enzmann, H. Zerban

      Pages 47-64

   5. Carcinogenic Risk Assessment: Are Animals Good Surrogates for Man?

      • I. F. H. Purchase

      Pages 65-79

5. Back Matter

   Pages 80-83

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6. Chemical Carcinogens: Primary Prevention

   1. Front Matter

      Pages 85-85

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   2. Possibilities of Primary Prevention Against Chemical Carcinogens

      • R. Preussmann

      Pages 87-93

   3. Primary Prevention Against Occupational Carcinogens

      • P. J. Landrigan, I. J. Selikoff

      Pages 94-100

   4. Chemical Carcinogens in Tobacco

      • D. Hoffmann, E. L. Wynder, S. S. Hecht, K. D. Brunnemann, E. J. La Voie, N. J. Haley

      Pages 101-113

   5. Primary Prevention of Tobacco-Related Cancer

      • E. L. Wynder, M. A. Orlandi

      Pages 114-132

7. Back Matter

   Pages 133-134

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8. Physical Carcinogens

   1. Front Matter

      Pages 135-135

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   2. Cancer Risk from Ultraviolet Radiation

      • H. Ippen

      Pages 137-142

   3. Assessment of Cancer Risks Due to Ionizing Radiations

      • A. M. Kellerer

      Pages 143-153

A large body of information about possible causes of cancer has been ac­ cumulated by both clinical experience in man and observations in animal experiments. There is general agreement that in most cases cancer is due to exogenous factors, albeit the genetic disposition may also play an impor­ tant part. Three main categories of exogenous risk factors have been iden­ tified, namely chemicals, radiation, and viruses. In principle, it should be possible to prevent cancer by eliminating such risk factors. However, in spite of the rapidly growing number of well established risk factors, many shortcomings in our understanding of the causes of human cancer and in the introduction of effective preventive measures are evident. In addition to obvious gaps in our scientific knowledge, inadequacies in personal life style, irresponsible handling of environmental contaminants, and in some areas also deficiencies in political decisions seriously hamper the elimina­ tion of risk factors for cancer. It was this background which prompted the Committee coordinating Cancer Research in the GroBforschungseinrichtungen in the Federal Re­ public of Germany to organize a conference on Strategies for the Elimina­ tion of Cancer Risks. The conference was held in Heidelberg in June 1986. In areas which appeared to be especially pertinent to public health, author­ itative speakers presented the state of the art and prepared the basis for the discussion. Both the presentations of the speakers and the summaries of the discussions are contained in this book.

• cancer
• cancer research
• epidemiology
• prevention

• Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany

  Peter Bannasch

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