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Receptor-Mediated Uptake in the Liver

  • Conference proceedings
  • © 1986

Overview

Editors:
  1. Heiner Greten

    1. Med. Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg 20, Germany

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  2. Eberhard Windler

    1. Med. Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg 20, Germany

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  3. Ulrike Beisiegel

    1. Med. Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg 20, Germany

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Table of contents (35 papers)

  1. Front Matter

    Pages I-X
    Download chapter PDF

  2. Mechanisms of Uptake and Processing of Macromolecules by the Liver

    • R. J. Havel
    Pages 1-5

  3. The LDL Receptor — Structural Insights

    • W. J. Schneider
    Pages 6-8

  4. Partial Purification and Characterization of Hepatic Low Density Lipoprotein (LDL) Receptor from Rabbit Liver

    • E. Gherardi, D. E. Bowyer
    Pages 9-14

  5. DNA Polymorphisms of the Low Density Lipoprotein (LDL) Receptor Gene

    • B. Horsthemke, Anna M. Kessling, R. Williamson, St. E. Humphries
    Pages 15-19

  6. LDL-Binding to Human Liver Plasma Membranes

    • G. Renaud, Jacqueline Marais, R. Infante
    Pages 20-27

  7. Detection of LDL Receptors in Liver Membranes by Ligand Blotting with Biotin-Modified Plasma Lipoproteins

    • D. P. Wade, B. L. Knight, Anne K. Soutar
    Pages 28-32

  8. Cellular Localization of Lipoprotein Receptors in Liver

    • Theo. J. C. van Berkel, J. Kar Kruijt, J. Fred Nagelkerke, Leen Harkes
    Pages 33-37

  9. Cell Density Dependent Uptake of LDL in Cultured Rat Hepatocytes

    • E. Jensen, C.-H. Florén, Åke Nilsson
    Pages 38-44

  10. APO-B, E Receptor Binding of LDL: Evidence for Species-specific Segments of APO-B100 in the Binding Site Domain

    • M. J. Chapman, F. Loisay, P. Forgez
    Pages 45-51

  11. Effect of the Phorbol Esters on the Receptors for LDL on U-937 Monocyte-Like Cells and Acetyl-LDL on Mouse Peritoneal Macrophages

    • S. Goldstein, M. Rouis, D. Erlich, M. Berthelier, C. Cherier, P. Thomopoulos
    Pages 52-55

  12. Regulation of Low Density Lipoprotein Levels in Animals and Man with Particular Emphasis on the Role of the Liver

    • J. M. Dietschy, D. K. Spady
    Pages 56-65

  13. Turnover of Light and Heavy Fractions of Human LDL in Normal and WHHL Rabbits

    • M. Kano, J. Koizumi, A. Jadhav, G. R. Thompson
    Pages 66-68

  14. Regulation of LDL Receptor Activity in Human Hepatocytes

    • L. Havekes, E. de Wit, H. Princen
    Pages 69-73

  15. Non-Genetic Regulation of LDL Metabolism: Role of Lipid Transfer Proteins and Hypertriglyceridemia

    • S. Eisenberg
    Pages 74-79

  16. The Control of Cholesterol Homeostasis: Regulation of HMG CoA Reductase

    • K. L. Luskey
    Pages 80-82

  17. Cholesterol and Bile Acid Synthesis as Related to Receptor and Non-receptor Mediated Degradation of LDL in Man

    • Y. Antero Kesäniemi, Tatu A. Miettinen
    Pages 83-86

  18. The Reticuloendothelial System and Low Density Lipoprotein Metabolism

    • J. Shepherd, C. J. Packard, S. A. W. Gibson
    Pages 87-90

  19. Removal of Chylomicron Remnants by the Hepatic LDL Receptor Liver — Possible Contribution of the Low Densitiy Lipoprotein Receptor

    • E. E. T. Windler, W. H. Därr, H. Greten
    Pages 91-96

  20. Metabolism of Human Triglyceride-rich Lipoprotein Remnants

    • C. J. Packard, A. Munro, R. J. Clegg, R. James, D. Pometta, J. Shepherd
    Pages 97-99
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Keywords

About this book

Cell surface receptors are multifunctional proteins with binding sites towards the external environment and effector sites which mediate intracellular events. The purpose of this symposium was to bring together investigators who have a com­ mon interest in those receptors which are located in the liver, and who have studied endocytic mechanisms for various macromolecules like insulin, lipoproteins, epi­ dermal growth factor and others. Experiments in this particular field of research date back to the early 60-ies but have only recently led to new and important in­ sight in the molecular basis of receptor mediated uptake in the liver. The structural features which control these mechanisms are currently under intense investigation in many laboratories. Though this symposium largely emphasizes lipoprotein up­ take and catabolism by the liver, it was the particular intention of the organizers to discuss methodology and results with investigators who are also interested in he­ patic uptake of macromolecules. This might then eventually lead to new and com­ mon concepts for both receptor-ligand interaction and internalization processes in the liver. Biochemists, pathologists and gastroenterologists met for two and a half days and discussed their latest data in this so rapidly developing field of basic rese­ arch. This conference is part of a series on current topics in gastroenterology and hepatology arranged regularly by the Departments of Medicine and Surgery at the University Hospital Eppendorf. If is our hope, that such exchange of information between the different disciplines in medicine will continue. i. k.

Editors and Affiliations

  • Med. Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg 20, Germany

    Heiner Greten, Eberhard Windler, Ulrike Beisiegel

Bibliographic Information

  • Book Title: Receptor-Mediated Uptake in the Liver

  • Editors: Heiner Greten, Eberhard Windler, Ulrike Beisiegel

  • DOI: https://doi.org/10.1007/978-3-642-70956-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1986

  • Softcover ISBN: 978-3-540-16181-3Published: 01 February 1986

  • eBook ISBN: 978-3-642-70956-2Published: 14 March 2013

  • Edition Number: 1

  • Number of Pages: X, 223

  • Number of Illustrations: 52 b/w illustrations

  • Topics: Hepatology, Gastroenterology

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