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Immunological Aspects of Liver Disease

  • Book
  • © 1982

Overview

Editors:
  1. Howard C. Thomas

    1. Academic Department of Medicine, The Royal Free Hospital and Medical School, Hampstead, London, Great Britain

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  2. Peter A. Miescher

    1. Division d’Hématologie du Department de Médicine Hôpital Cantonal, Genève, Switzerland

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  3. Hans J. Mueller-Eberhard

    1. Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

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Table of contents (14 chapters)

  1. Front Matter

    Pages I-VI
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  2. Introduction

    • Howard C. Thomas
    Pages 1-5

  3. Genetic Determinants of Autoimmune Chronic Active Hepatitis

    • Ian R. Mackay, Senga Whittingham, John D. Mathews, Brian D. Tait
    Pages 7-18

  4. The Role of Liver Membrane Antigens as Targets in Autoimmune Type Liver Disease

    • K. H. Meyer zum Büschenfelde, T. H. Hütteroth, M. Manns, B. Möller
    Pages 19-37

  5. Immunologic Effector Mechanisms in Hepatitis B-Negative Chronic Active Hepatitis

    • R. James Klingenstein, Jack R. Wands
    Pages 39-51

  6. Drug-Induced Chronic Hepatitis

    • Ralph Wright
    Pages 53-60

  7. Clinical, Histologic, and Immunopathologic Features of Primary Biliary Cirrhosis

    • Hans Popper, Fiorenzo Paronetto
    Pages 61-76

  8. Serology of Primary Biliary Cirrhosis

    • Peter A. Berg, Harold Baum
    Pages 77-95

  9. Pathogenic Mechanisms in Primary Biliary Cirrhosis

    • H. C. Thomas, O. Epstein
    Pages 97-106

  10. Hepatic Transplantation

    • Roy Calne
    Pages 107-115

  11. The Nature of the Hepatitis B Virus and its Mode of Replication

    • C. R. Howard
    Pages 117-139

  12. The Immunopathology of Acute Type B Hepatitis

    • Leonardo Bianchi
    Pages 141-158

  13. The Immunopathogenesis of Chronic HBV Induced Liver Disease

    • Gary A. Levy, Francis V. Chisari
    Pages 159-179

  14. Immunopathogenesis of the Extrahepatic Manifestations of Hepatitis B Virus Infection

    • Jules L. Dienstag
    Pages 181-192

  15. Primary Liver Cancer and Its Relationship to Chronic Infection with the Hepatitis B Virus

    • Stephanos J. Hadziyannis
    Pages 193-205

  16. Back Matter

    Pages 207-210
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Keywords

About this book

Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of a change in the antigenicity of the tissues (secondary autoimmunization). Autoaggressive reactions are characterised by the presence of autoantibodies. When these are directed to membrane displayed antigens (Fig. 1) they are probably of importance in the lysis of hepatocytes. Those directed to cytoplasmic antigens may be useful diagnostically but are of unknown pathogenic significance. When no extrinsic aetiological factor can be identified, the process is assumed to be the result of a failure ofthe regulatory system, allowing the spontaneous expansion of a clone of autoreactive lymphocytes. The defect may be generalised or specific to certain groups of self-antigens and thus the autoimmune disease may be either multi- or unisystemic. The recent development of techniques to enumerate and measure the functional activity of the suppressor lymphocytes which control the effector limbs of the immune system has enabled investigators to test whether the various purported autoimmune diseases do have as their basis a generalised defect in immunoregu­ lation. Assessment of antigen-specific immunoregulatory function is, however, not yet readily available. liver Membrane I Antigen (LIM) I Liver I HLA, A, B, C, Sensitisation to Specific -;::!IIIL. .

Editors and Affiliations

  • Academic Department of Medicine, The Royal Free Hospital and Medical School, Hampstead, London, Great Britain

    Howard C. Thomas

  • Division d’Hématologie du Department de Médicine Hôpital Cantonal, Genève, Switzerland

    Peter A. Miescher

  • Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

    Hans J. Mueller-Eberhard

Bibliographic Information

  • Book Title: Immunological Aspects of Liver Disease

  • Editors: Howard C. Thomas, Peter A. Miescher, Hans J. Mueller-Eberhard

  • DOI: https://doi.org/10.1007/978-3-642-68446-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1982

  • Softcover ISBN: 978-3-540-11310-2Published: 01 April 1982

  • eBook ISBN: 978-3-642-68446-3Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VI, 210

  • Number of Illustrations: 9 b/w illustrations

  • Additional Information: Monograph edition of: Springer Seminars in Immunopathology, Vol. 3, 3-4

  • Topics: Hepatology, Gastroenterology, Allergology, Immunology

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