Immunostimulation

1. Front Matter

   Pages I-VIII

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2. Immunostimulation

   • Louis Chedid

   Pages 1-3

3. Adjuvants and Immune Regulation by Lymphoid Cells

   • Byron H. Waksman

   Pages 5-33

4. The Immunopharmacology of Immunotherapy

   • John W. Hadden

   Pages 35-48

5. Immunoregulation by Parasite Extracts

   • André Capron, Daniel Camus

   Pages 49-57

6. Lipopolysaccharides: From Immunostimulation to Autoimmunity

   • Jacques A. Louis, Paul-Henri Lambert

   Pages 59-72

7. Immunoregulation by Bacterial Organisms and Their Role in the Immunotherapy of Cancer

   • R. W. Baldwin, V. S. Byers

   Pages 73-94

8. Cord Factor and Related Synthetic Trehalose Diesters

   • Edgar Lederer

   Pages 95-110

9. Biologic Properties of a New Synthetic Adjuvant, Muramyl Dipeptide (MDP)

   • Monique Parant

   Pages 111-128

10. Thymosin and Other Thymic Hormones and Their Synthetic Analogues

    • Teresa L. K. Low, Allan L. Goldstein

    Pages 129-146

11. Immunostimulation by an Ig Derived Tetrapeptide, Tuftsin

    • E. Tzehoval, S. Segal, Y. Stabinsky, M. Fridkin, Z. Spirer, M. Feldman

    Pages 147-156

12. Modulation of the Immune System by Synthetic Polynucleotides

    • Arthur G. Johnson

    Pages 157-176

13. Lysophosphatidylcholine (Lysolecithin) and its Synthetic Analogues. Immunomodulating and Other Biologic Effects

    • P. G. Munder, M. Modolell, R. Andreesen, H. U. Weltzien, O. Westphal

    Pages 177-193

14. Immunoregulation with Levamisole

    • J. Symoens, M. Rosenthal, M. De Brabander, G. Goldstein

    Pages 195-214

15. The Challenge of the Combined Use of Synthetic Antigens and Synthetic Adjuvants

    • Michael Sela, Edna Mozes

    Pages 215-228

16. Conclusions

    • L. Chedid, P. A. Miescher

    Pages 229-232

17. Back Matter

    Pages 233-238

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The discovery of specifically acquired immunity which followed the major contributions of Louis Pasteur completely over-shadowed the first studies of the host's natural resistance. Later, the exquisite sensitivity and precision of antigen-antibody reactions made the study of immunochemistry much more attractive than the rather primitive and ambiguous field of non-specific immunity. Neverthe­ less, during the last three decades, a considerable body of informa­ tion was developed and also means by which natural resistance could be enhanced or depressed by exogenous agents such as lipopolysaccharides or BCG. An important advance was the chemical recognition of the biologically active components of these agents which in turn allowed the synthesis or" analogues. More recently, endogenous host products which can play a role in nonspecific immunity, such as thymic hormones, have also been identified, produced and used both experimentally and clinically. It therefore seemed worthwile to Drs. Miescher and Mueller-Eberhard to devote two volumes of Seminars in Immunopathology to the topic of Immunostimuhltion. Because of the good response obtai­ ned from readers, Springer Verlag decided to issue a hard cover book and asked their guest editor to make a preface. Prefaces, although they are found in the opening pages, are always written after the first issue has been completed.

• Antigen
• Immunotherapie
• autoimmunity
• bacteria
• immunotherapy
• parasite
• pathology
• pharmacology
• resistance

• Immunothérapie Expérimentale, Institut Pasteur, Paris, France

  Louis Chedid

• Division d’Hématologie du Departement de Médecine, Hôpital Cantonal, Genève, Switzerland

  Peter A. Miescher

• Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

  Hans J. Mueller-Eberhard

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