Mechanism of Toxic Action on Some Target Organs

1. Front Matter

   Pages I-X

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2. Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity

   1. Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity

      • J. A. Timbrell

      Pages 1-8

3. The Influence of the Neuro-Endocrine System on the Toxic Reactions Due to Hormones and Other Compounds

   1. Front Matter

      Pages 9-9

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   2. Evaluation of Effects of Sexual Steroids on the Hypothalamic-Pituitary System of Animals and Man

      • M. F. El Etreby, K. J. Gräf, P. Günzel, F. Neumann

      Pages 11-39

   3. Ultrastructure of Intermediate Lobe of the Pituitary and Melanocyte-Stimulating Hormone Secretion in Oestrogen-Induced Kidney Tumours in Male Hamsters

      • P. G. Saluja, J. M. Hamilton, A. J. Thody, A. A. Ismail, J. Knowles

      Pages 41-45

   4. Role of Neuroendocrine System in Regulation of Mammary Tumors in Different Species

      • J. Meites

      Pages 47-58

   5. Evaluation of the Carcinogenic Effects of Estrogens, Progestins and Oral Contraceptives on Cervix, Uterus and Ovary of Animals and Man

      • V. A. Drill

      Pages 59-84

   6. Assessment of ACTH-Adrenal Activity After Treatment with a Glucocorticoid and an Antiandrogenic Steroid

      • J. Girard, J. B. Baumann, S. Graf, G. van Hees, M. Rosenthal, K. Zuppinger

      Pages 85-92

   7. Neuroendocrine Effects of Neuropsychotropic Drugs and Their Possible Influence on Toxic Reactions in Animals and Man — The Role of the Dopamine-Prolactin System

      • R. Horowski, K.-J. Gräf

      Pages 93-104

   8. Motility and Stereotyped Behaviour Induced by Amphetamine and Apomorphine on Hypophysectomized and on Thyroidectomized Rats

      • A. Benakis

      Pages 105-109

4. Induction of Adaptive and Malignant Liver Growth by Drugs and Environmental Pollutants

   1. Front Matter

      Pages 111-111

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   2. Adaptive Liver Growth Induced by Xenobiotic Compounds: Its Nature and Mechanism

      • R. Schulte-Hermann

      Pages 113-124

   3. Growth Control in Regenerating Rat Liver

      • K. Weinbren

      Pages 125-130

   4. Control of Liver Growth by Growth Inhibitors (Chalones)

      • C. Nadal

      Pages 131-142

   5. Nucleic Acid and Pyrimidine Nucleotide Metabolism During Liver Growth Induced by Xenobiotic Compounds

      • J. Seifert, E. Buchar

      Pages 143-144

   6. Early Biological Markers During Liver Carcinogenesis

      • P. Bannasch, H.-J. Hacker, D. Mayer

      Pages 145-155

   7. Correlation of Liver Growth and Function During Liver Regeneration and Hepatocarcinogenesis

      • H. Barbason, V. Smoliar, J. Van Cantfort

      Pages 157-169

   8. Liver Growth and Tumorigenesis in Rats

      • P. Grasso

      Pages 171-180

   9. Liver Tumors and Steroid Hormones in Rats and Mice

      • J. Schuppler, P. Günzel

      Pages 181-195

   10. The Effects of Dieldrin, Diet and Other Environmental Components on Enzyme Function and Tumour Incidence in Livers of CF-1 Mice

       • H. A. Tennekes, A. S. Wright, K. M. Dix

       Pages 197-212

The first oral contraceptive became available in 1960 and since then these sub­ stances, which have been used by millions of women, have probably been the most widely studied group of drugs in medical history (Drill, 1966, 1977). Part of the evaluation oCoral contraceptives has involved their effect on the reproductive organs of women, with particular attention directed to evaluation of a possible carcinogenic effect of these steroids. To the extent that cancer of the reproductive organs is a common finding in women, the endogenous female sex hormones have been implicated in the occur­ rence of the cancer. The administration of estrogen has also been reported to in­ crease the incidence of cancer of the breast, cervix or endometrium in some strains or species of animals. Thus, because of the possible tumorigenic effect of estrogens there has been considerable interest in the relationship of oral contraceptives to cancer of the breast and genital tract.

• Drogen
• Thymus
• amphetamine
• assessment
• cancer
• cell
• dopamine
• environment
• ethanol
• pathology
• pharmacokinetics
• pollutants
• steroids
• toxicology
• xenobiotic

• Dept. of Pharmacology, Trinity College, Dublin 2, Ireland

  Philip L. Chambers

• Dept. of Exp. Toxicology, Schering AG, Berlin-Bergkamen, Germany

  Peter Günzel

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