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Red Cell Rheology

  • Conference proceedings
  • © 1978

Overview

Editors:
  1. Marcel Bessis

    1. Institut de Pathologie Cellulaire, Hôpital de Bicêtre, Bicêtre, France

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  2. Stephen B. Shohet

    1. School of Medicine, Cancer Research Center, The University of California, San Francisco, USA

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  3. N. Mohandas

    1. School of Medicine, Cancer Research Institute, University of California, San Francisco, USA

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Table of contents (34 papers)

  1. Front Matter

    Pages 1-7
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  2. Part I

    1. Front Matter

      Pages 9-9
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    2. Methods for Evaluation of Red Cell Deformability

      1. Intravascular Rheology of Erythrocytes in Man
        • P.-I. Brånemark, U. Bagge
        Pages 11-24
      2. The Aspiration of Red Cell Membrane into Small Holes: New Data
        • J. Douglas Brailsford, Ralph A. Korpman, Brian S. Bull
        Pages 25-38
      3. Red Cell Membrane Deformability: an Examination of Two Apparently Disparate Methods of Measurement
        • Brian S. Bull, J. Douglas Brailsford, Ralph A. Korpman
        Pages 39-54
      4. Basic Principles of the ‘Filterability Test’ (FT) and Analysis of Erythrocyte Flow Behavior
        • Paul Teitel
        Pages 55-70
      5. Principles and Techniques for Assessing Erythrocyte Deformability
        • Shu Chien
        Pages 71-99
      6. Viscometric Techniques and the Rheology of Blood
        • Winfred M. Phillips
        Pages 101-111

    3. Biochemical Basis for Red Cell Shape and Deformability

      1. Possible Roles for Membrane Protein Phosphorylation in the Control of Erythrocyte Shape
        • Stephen B. Shohet, Alfred C. Greenquist
        Pages 115-133
      2. Human Red Cell Protein Kinase in Normal Subjects and Patients with Hereditary Spherocytosis, Sickle Cell Disease, and Autoimmune Hemolytic Anemia
        • E. Beutler, E. Guinto, C. Johnson
        Pages 135-152
      3. Role of ATP Depletion on Red Cell Shape and Deformability
        • C. Feo, N. Mohandas
        Pages 153-161
      4. The Effects of ATP Depletion on the Response of Erythrocytes to Shear Stress
        • K. Tadano, J. D. Hellums, E. C. Lynch, E. J. Peck, C. P. Alfrey
        Pages 163-174
      5. Effect of Protein Modification on Erythrocyte Membrane Mechanical Properties
        • Robert S. Heusinkveld, David A. Goldstein, Robert I. Weed, Paul L. Lacelle
        Pages 175-182
      6. Effect of Protein Modification on Erythrocyte Membrane Mechanical Properties
        • Robert S. Heusinkveld, David A. Goldstein, Robert I. Weed, Paul Lacelle
        Pages 183-184

    4. Clinical Applications

      1. Antibody-Induced Spherocytic Anemia I. Changes in Red Cell Deformability
        • Narla Mohandas, Anne de Boisfleury
        Pages 187-196
      2. Antibody-Induced Spherocytic Anemia II. Splenic Passage and Sequestration of Red Cells
        • Anne de Boisfleury, Narla Mohandas
        Pages 197-205
      3. Discussion of Papers
        • A. de Boisfleury, N. Mohandas
        Pages 206-208
      4. Red Cell Deformability Changes in Hemolytic Anemias Estimated by Diffractometric Methods (Ektacytometry) Preliminary Results
        • C. Allard, N. Mohandas, M. Bessis
        Pages 209-221

  3. Part II

    1. Front Matter

      Pages 223-223
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    2. Sickle Cell Rheology

      1. Laser Diffraction Patterns of Sickle Cells in Fluid Shear Fields
        • Marcel Bessis, Narla Mohandas
        Pages 225-235
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Keywords

About this book

Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical forces than extents of hemolysis, we performed a series of experi­ ments repeating some of the conditions reported in [I] and then focusing on low L1P in order to define better the thresholds of hemolysis for several pore sizes. Employing a model of a deformed red cell shape at the pore entrance (based on micropipette observations) we related the force field in the fluid to a biaxial tension in the membrane. The threshold for lysis correlated with a membrane tension of 30 dynes/cm. This quantity is in agreement with lysis data from a number of other investigators employing a variety of mechanisms for introduc­ ing membrane tension. The sequence of events represented here is: a. Fluid forces and pressure gradients deform the cell into a new, elongated shape. b. Extent of deformation becomes limited by the resistance of the cell mem­ brane to undergo an increase in area. c. Fluid forces and pressure gradients acting on the deformed cell membrane cause an increase in biaxial tension in the membrane. d. When the strain caused by this tension causes pores to open in the membrane, the threshold for hemolysis has been reached [2].

Editors and Affiliations

  • Institut de Pathologie Cellulaire, Hôpital de Bicêtre, Bicêtre, France

    Marcel Bessis

  • School of Medicine, Cancer Research Center, The University of California, San Francisco, USA

    Stephen B. Shohet

  • School of Medicine, Cancer Research Institute, University of California, San Francisco, USA

    N. Mohandas

Bibliographic Information

  • Book Title: Red Cell Rheology

  • Editors: Marcel Bessis, Stephen B. Shohet, N. Mohandas

  • DOI: https://doi.org/10.1007/978-3-642-67059-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1978

  • Softcover ISBN: 978-3-540-09001-4Published: 01 October 1978

  • eBook ISBN: 978-3-642-67059-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 440

  • Number of Illustrations: 74 b/w illustrations

  • Additional Information: Originally published as Vol. 3, issues 1-2 of the journal "Blood Cells"

  • Topics: Solid Mechanics, Biomedicine general, Life Sciences, general

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