Cardiac Glycosides

1. Front Matter

   Pages I-XIII

   PDF

2. Evaluation of Different Methods for Determining Serum Concentrations of Cardiac Glycosides

   • V. P. Butler Jr.

   Pages 1-21

3. A New Simple Assay for Determining Digoxin Serum Levels

   • K. Stellner

   Pages 22-27

4. Chloroform-Extractable and Polar Metabolites Examined With Different Assays

   • U. Gundert-Remy, K. Koch, V. Hrstka

   Pages 28-35

5. Studies of the Metabolism of Digoxin and Digitoxin Using Double Isotope Dilution Derivative Methods

   • D. S. Lukas

   Pages 36-51

6. Occurence and Chemical Nature of Polar Water-Soluble Digoxin Metabolites

   • H. F. Benthe

   Pages 52-63

7. Pharmacokinetics and Metabolism of Digitoxin in the Human

   • H. F. Vöhringer, N. Rietbrock

   Pages 64-73

8. Dihydrodigitoxin, a Metabolite of Digitoxin in Humans

   • G. Bodem, E. v. Unruh

   Pages 74-84

9. Enterohepatic Circulation of Digitoxin Metabolites in the Dog

   • G. Ch. Oliver, L. A. Santini, G. Griffin, R. Ruffy

   Pages 85-92

10. β-Methyl-Digoxin, a New Lipophilic Digoxin Derivative

    • W. Schaumann

    Pages 93-108

11. Tissue Distribution of Cardiac Glycosides

    • J. Kuhlmann, N. Rietbrock, B. Schnieders

    Pages 109-125

12. Plasma-Tissue Distribution of Different Cardiac Glycosides

    • D. Larbig, R. Haasis

    Pages 126-134

13. Significance of Plasma Concentration of Digoxin in Relation to the Myocardial Concentration of the Drug

    • J. Coltart

    Pages 135-158

14. Influence of Thyroid Function on the Pharmacokinetics of Cardiac Glycosides

    • H. J. Gilfrich, T. Meinertz

    Pages 159-166

15. Effect of Jejunoileal Bypass on the Bioavailability of Digoxin in Man

    • F. I. Marcus, D. Perrier, M. Mayersohn

    Pages 167-180

16. Bioavailability of Digoxin in Renal Insufficiency and Heart Failure

    • E. E. Ohnhaus

    Pages 181-186

17. Bioavailability Studies: Their Influence on the Clinical Use of Digitalis

    • T. R. D. Shaw

    Pages 187-198

18. Comparative Pharmacokinetics of Various Digoxin Preparations in Man

    • P. F. Binnion

    Pages 199-210

19. Digoxin Pharmacokinetics and Their Relation to Clinical Dosage Parameters

    • H. J. Dengler, G. Bodem, H. J. Gilfrich

    Pages 211-225

20. Clinical Interpretation of Serum Concentrations of Cardiac Glycosides

    • T. W. Smith, L. H. Green, G. D. Curfman

    Pages 226-241

In spite of old vintage and 200 years of clinical use, digitalis remains an interesting therapeutic agent, to clinicians as well as to the pharmacologist, the biochemist, and colleagues in other diciplines of theoretic medicine. When a drug, however, has so many attractive facets, it seems proper and aJvis­ able for the success of a scientific meeting to focus on a number of well-defined aspects. This symposium was devoted to pharmacokinetics, drug metabolism, analytic procedures, blood level determinations, and their interpretation both for thera­ peutic and toxic situations. Considerable progress has been made during the last years in this area of digitalis research. The time was suitable for a critical reap­ praisal of facts and theories and for future planning. Our main intention was to relate analytic data and biochemical findings to clinical problems and questions. Despite the undoubtedly basic character of clinical pharmacology, it is neverthe­ less an applied science which should help to develop the rational basis of thera­ peutics. We are particularly grateful to the active participants who bore the burden of preparing presentations and - even worse - manuscripts. At the same time we are well-aware that many other active research groups would have been able to contribute in this way, but our program was limited because of the short time available. Their knowledge is included in the discussion parts of the meeting, so we hope a well-balanced description of the present state of affairs emerged in this volume.

• Bypass
• Herzglykosid
• assessment
• circulation
• heart
• heart failure
• medicine
• pharmacodynamics
• pharmacology
• planning

• Medizinische Universitäts-Klinik, Bonn-Venusberg, Germany

  Günter Bodem, Hans J. Dengler

Policies and ethics