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2nd International Adalat® Symposium

New Therapy of Ischemic Heart Disease

  • Conference proceedings
  • © 1975

Overview

Editors:
  1. Wilhelm Lochner

    1. Physiolog. Institut der Universität, Düsseldorf, Fed. Rep. Germany

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  2. Wolfgang Braasch
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  3. Günther Kroneberg

    1. Bayer AG, Pharma Research Development, Fed. Rep. Germany

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Table of contents (47 papers)

  1. Front Matter

    Pages I-XVIII
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  2. Introduction

    1. Introduction

      • W. Lochner
      Pages 1-1

  3. Present Basis of Coronary Therapy

    1. Present Basis of Coronary Therapy

      • W. Lochner
      Pages 2-10

  4. Chemistry and Experimental Pharmacology

    1. Front Matter

      Pages 11-11
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    2. Pharmacology of Nifedipine

      • G. Kroneberg
      Pages 12-19

    3. The Chemistry of Nifedipine

      • F. Bossert
      Pages 20-26

    4. Pharmacokinetics of Adalat in Animal Experiments

      • K. Patzschke, B. Duhm, W. Maul, H. Medenwald, L. A. Wegner
      Pages 27-32

    5. Investigations on the Metabolism and Protein Binding of Nifedipine

      • K. Schlossmann, H. Medenwald, H. Rosenkranz
      Pages 33-39

    6. Experimental Pharmacological Investigations of Effects of Nifedipine on Atrioventricular Conduction in Comparison with Those of Other Coronary Vasodilators

      • N. Taira, S. Motomura, A. Narimatsu, T. Iijima
      Pages 40-48

    7. Studies on the Extracardial Effects of Nifedipine in Anesthetized Dogs

      • K. Hagemann, W. Lochner, B. Niehues
      Pages 49-54

  5. Experimental Pharmacology

    1. Front Matter

      Pages 55-55
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    2. Adalat, a Powerful Ca-Antagonistic Drug

      • A. Fleckenstein
      Pages 56-65

    3. Ca-Dependent Changes in Coronary Smooth Muscle Tone and the Action of Ca-Antagonistic Compounds with Special Reference to Adalat

      • G. Fleckenstein-Grün, A. Fleckenstein
      Pages 66-76

    4. Myocardial Oxygen Consumption under the Influence of Nifedipine (Adalat) in the Anesthetized Dog

      • W. Vater
      Pages 77-81

    5. Hemodynamic Effects of Adalat in the Unanesthetized Dog

      • H. Kirchheim, R. Gross
      Pages 82-91

    6. Investigations on the Development of Collaterals, Coronary Flow, Tachyphylaxis and Steal Phenomenon in Dogs after Application of Adalat

      • J. Schmier, K. van Ackern, U. B. Brückner, B. Hakimi, W. Heger, J. Simo
      Pages 92-100

    7. The Effect of Adalat on the Mechanical and Electrical Activity of Isolated Rat Cardiac Muscle, with Special Reference to Calcium Antagonism of the Compound

      • K. Landmark, H. Refsum
      Pages 101-110

  6. Clinical Pharmacology

    1. Front Matter

      Pages 111-111
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    2. Hemodynamic Studies on Adalat in Healthy Volunteers and in Patients

      • H. Lydtin, G. Lohmöller, R. Lohmöller, H. Schmitz, I. Walter
      Pages 112-123

    3. Pharmacokinetics of Nifedipine-14C in Man

      • F. A. Horster
      Pages 124-127
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Keywords

About this book

The First Adalat Symposium held in Tokyo in 1973, presented important experimental and clinical results which had been collected in Europe and Japan with the new coronary therapeutic agent. The European scientists had an opportunity to discuss the problems and results personally with their Japanese colleagues. The Second Adalat Symposium was held in Amsterdam within a year with the purpose of bringing together mainly scientists within Europe. The results discussed in Tokyo have been extended and supplemented through additional experiences. Contributions in basic science are presented, but most important are those clinical studies, which support and extend proof of the drug's efficacy in humans. The editors wish to express their appreciation to all those responsible for contributing to this report and, in particular, to Dr. M. SPENGLER, Dr. F. EBNER and Dr. K. BRANDAU for their editorial help, and to Dr. W. BOTTGER for the preparation of the Subject Index. We hope that this publication will be a valuable contribution toward conveying information to physicians and scientists. DiisseldorfjWuppertal, Autumn 1975 W. LOCHNER' W BRAASCH' G. KRONEBERG Contents Introduction: W. LOCHNER Present Basis of Coronary Therapy: W. LOCHNER. With 11 Figures 2 Session I. Chemistry and Experimental Pharmacology (Chairmen: A. FLECKENSTEIN and K. LANDMARK) Pharmacology of Nifedipine: G. KRONEBERG. With 8 Figures 12 Discussion Remarks 19 The Chemistry of Nifedipine: F. BOSSERT. With 9 Figures 20 Pharmacokinetics of Adalat in Animal Experiments: K. PATZSCHKE, B.

Editors and Affiliations

  • Physiolog. Institut der Universität, Düsseldorf, Fed. Rep. Germany

    Wilhelm Lochner

  • Bayer AG, Pharma Research Development, Fed. Rep. Germany

    Günther Kroneberg

Bibliographic Information

  • Book Title: 2nd International Adalat® Symposium

  • Book Subtitle: New Therapy of Ischemic Heart Disease

  • Editors: Wilhelm Lochner, Wolfgang Braasch, Günther Kroneberg

  • DOI: https://doi.org/10.1007/978-3-642-66241-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1975

  • Softcover ISBN: 978-3-540-07471-7Published: 01 December 1975

  • eBook ISBN: 978-3-642-66241-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVIII, 372

  • Topics: Cardiology

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