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Unclassifiable Leukemias

Proceedings of a Symposium, held on October 11 - 13, 1974 at the Institute of Cell Pathology, Hopital de Bicetre, Paris, France.

  • Conference proceedings
  • © 1975

Overview

Editors:
  1. Marcel Bessis

    1. Institut de Pathologie Cellulaire, Hôpital de Bicêtre, Kremlin-Bicêtre, France

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  2. George Brecher

    1. School of Medicine Department of Clinical Pathology and Laboratory Medicine, University of California, San Francisco, USA

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Table of contents (45 papers)

  1. Front Matter

    Pages I-VIII
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  2. Present Practice of Classification, its Utility and Limitations

    1. Front Matter

      Pages 1-1
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    2. Introduction

      • Jean Bernard
      Pages 3-5

    3. Cytological Classification of Acute Leukemias A Survey of 1400 Cases

      • G. Flandrin, Jean Bernard
      Pages 7-15

    4. Classification of the Acute Leukaemias

      • D. A. G. Galton, J. V. Dacie
      Pages 17-24

    5. Leukaemic Lymphosarcomas: Respective Prognosis of the Three Types: Prolymphocytic, Lymphoblastic (or Lymphoblastoid) and Immunoblastic

      • G. Mathé, D. Belpomme, D. Dantchev, P. Pouillart, J. R. Schlumberger, M. Lafleur
      Pages 25-36

    6. Search for Correlations between Cytological Types and Therapeutic Sensitivity of Acute Leukaemias

      • G. Mathé, D. Belpomme, D. Dantchev, P. Pouillart, L. Navares, G. Hauss et al.
      Pages 37-52

    7. Answers to Submitted Questions

      • Marcel Bessis, George Brecher
      Pages 53-56

    8. Open Discussion of Section I

      • Marcel Bessis, George Brecher
      Pages 57-60

  3. New Techniques Used in Cytological Diagnosis

    1. Front Matter

      Pages 61-61
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    2. Fluorescence Probe and Biochemical Characterization of Leukaemic Cells

      • L. G. Lajtha
      Pages 63-65

    3. Discussion

      • Marcel Bessis, George Brecher
      Pages 67-70

    4. Automated Cell Population Analysis

      • Bo Thorell
      Pages 71-77

    5. Discussion

      • Marcel Bessis, George Brecher
      Pages 79-80

    6. The Use of B and T Membrane Markers in the Classification of Human Leukemias, with Special Reference to Acute Lymphoblastic Leukemia

      • Jean-Claude Brouet, Jean-Louis Preud’Homme, Maxime Seligmann
      Pages 81-90

    7. Discussion

      • Marcel Bessis, George Brecher
      Pages 91-94

    8. Volumetric Determinations of Blood Cells in Acute Lymphoblastic Leukemia

      • J. L. Binet, G. Dighiero, P. D’Athis, M. Feinermann, F. de Montaut, J. Seroude
      Pages 95-97

    9. Discussion

      • Marcel Bessis, George Brecher
      Pages 99-99

    10. Acute Leukemia Cytochemical Profile: Diagnostic and Clinical Implications

      • John M. Bennett, Carolyn E. Reed
      Pages 101-108

    11. Discussion

      • Marcel Bessis, George Brecher
      Pages 109-113
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Keywords

About this book

Jean BERNARD * I should like to begin with an assumption and a paradox. The assumption is that leukemia is a disease of a stem cell characterized by pathologie alterations of that cell and its progeny. All present research and discussions are centered around the leukemic cell. So is this symposium, which would not take place except for our primary interest in the leukemic cell. This does not preclude, of course, consideration of other definitions and other approaches to the prOblem. By definition, then, the leukemic cells are abnormal cells and their metabolism and functions are presumed to be abnormal. Yet, the classification of the different types of leukemias is based upon the characteristics of normal cells. We talk of "lymphoblasts" and "myeloblasts" as predominant cell types in leukemia. This leads to a double paradox. In the first pi ace it is clearly illogical to classify abnormal cells by their resemblance to normal cells, since their very abnormality consists in not being normal. Yet, as a second paradox, the classifica­ ti on has had the happy consequence of ai ding us in the treatment and prognosis of leukemia for the past 25 years. A more detailed analysis shows that the consequence of this paradox are complex: while there exists a useful correlation between cellular types, treatment and prognosis, numerous problems and difficulties persist. The most serious of them concems the "unclassified leukemias" which are the reason for this reunion.

Editors and Affiliations

  • Institut de Pathologie Cellulaire, Hôpital de Bicêtre, Kremlin-Bicêtre, France

    Marcel Bessis

  • School of Medicine Department of Clinical Pathology and Laboratory Medicine, University of California, San Francisco, USA

    George Brecher

Bibliographic Information

  • Book Title: Unclassifiable Leukemias

  • Book Subtitle: Proceedings of a Symposium, held on October 11 - 13, 1974 at the Institute of Cell Pathology, Hopital de Bicetre, Paris, France.

  • Editors: Marcel Bessis, George Brecher

  • DOI: https://doi.org/10.1007/978-3-642-66126-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heildelberg 1975

  • Softcover ISBN: 978-3-540-07242-3Published: 01 November 1975

  • eBook ISBN: 978-3-642-66126-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 272

  • Number of Illustrations: 24 b/w illustrations

  • Additional Information: Originally published as Vol.1, issue 1 of the journal: "Blood Cells"

  • Topics: Hematology, Oncology

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