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Steroids and Brain Edema

Proceedings of an International Workshop, held in Mainz, W. Germany, June 19 to 21, 1972

  • Conference proceedings
  • © 1972

Overview

Editors:
  1. H. J. Reulen

    1. Neurochirurgische Universitätsklinik Mainz, Mainz, W. Germany

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  2. K. Schürmann

    1. Neurochirurgische Universitätsklinik Mainz, Mainz, W. Germany

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Table of contents (29 papers)

  1. Front Matter

    Pages I-XII
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  2. Experimental Aspects of Brain Edema and Therapeutic Approach

    1. Pathophysiological Aspects of Brain Edema

      • Igor Klatzo
      Pages 1-8

    2. Functional Aspects of Abnormal Protein Passage Across the Blood-Brain Barrier

      • K.-A. Hossmann, Y. Olsson
      Pages 9-17

    3. The Effects of Hypertonic Urea on the Blood-Brain Barrier and on the Glucose Transport in the Brain

      • Maria Spatz, Zbigniew M. Rap, Stanley I. Rapoport, Igor Klatzo
      Pages 19-27

    4. Molecular Aspects of Membrane Structure in Cerebral Edema

      • Harry B. Demopoulos, Paul Milvy, Sophia Kakari, Joseph Ransohoff
      Pages 29-39

    5. Some Aspects of the Pharmacology of Adrenal Steroids and the Central Nervous System

      • C. D. Withrow, Dixon M. Woodbury
      Pages 41-55

  3. Effects of Steroids on Experimental Brain Edema

    1. Effects of Steroids on Cold Injury Edema

      • Hanna M. Pappius
      Pages 57-63

    2. The Effects of Glucosteroids upon Experimental Brain Edema

      • Don M. Long, Robert E. Maxwell, Lyle A. French
      Pages 65-76

    3. The Influence of Dexamethasone on Water Content, Electrolytes, Blood-Brain Barrier and Glucose Metabolism in Cold Injury Edema

      • H.-D. Herrmann, D. Neuenfeldt, J. Dittmann, H. Palleske
      Pages 77-85

    4. Multiple Therapeutic Approaches in the Treatment of Brain Edema Induced by a Standard Cold Lesion

      • Don M. Long, Robert E. Maxwell, Kil Soo Choi, Harry O. Cole, Lyle A. French
      Pages 87-94

    5. Steroid-Induced Inhibition of Growth in Glial Tumors: a Kinetic Analysis

      • Charles B. Wilson, Marvin Barker, Takao Hoshino, Anthony Oliver, Robert Downie
      Pages 95-100

    6. Effects of Steroids on Edema Associated with Injury of the Spinal Cord

      • Marcial G. Lewin, Hanna M. Pappius, Robert R. Hansebout
      Pages 101-112

    7. Effect of Dexamethasone on Triethyl Tin Induced Brain Edema and the Early Edema in Cerebral Ischemia

      • Barry A. Siegel, Rebecca K. Studer, E. James Potchen
      Pages 113-121

    8. Effects of Ischemia on Water and Electrolyte Content of Cerebral Tissues

      • S. Shibata, J. W. Norris, C. P. Hodge, H. M. Pappius
      Pages 123-125

    9. Effect of Dexamethasone on the Early Edema Following Occlusion of the Middle Cerebral Artery in Cats

      • Daniel Bartko, Hans J. Reulen, Herrmann Koch, Kurt Schürmann
      Pages 127-137

  4. Mechanisms of Action of Steroids on Brain Edema

    1. Physiology and Pathophysiology of Protein Permeability in the Central Nervous System

      • Charles F. Barlow
      Pages 139-146

    2. Studies on the Mechanisms of Action of Steroids in Traumatized Brain

      • H. P. Tutt, Hanna M. Pappius
      Pages 147-151

    3. Evidence Regarding the Action of Steroids in Injured Spinal Cord

      • Robert R. Hansebout, Marcial G. Lewin, Hanna M. Pappius
      Pages 153-155

    4. The Role of Necrosis and Inflammation in the Response of Cerebral Edema to Steroids

      • Raymond A. Clasen, Walid A. Hindo, Sylvia Pandolfi, Iris Laing
      Pages 157-166

    5. Effect of Antioxidants on Experimental Cold-Induced Cerebral Edema

      • Bienvenido D. Ortega, Harry B. Demopoulos, Joseph Ransohoff
      Pages 167-175
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Keywords

About this book

The control of brain edema is still one of the major problems in surgical and conservative treatment of various cerebral lesions. Many attempts have been made to develop methods for reducing the high mortality associated with brain edema. Mter many years of using hypertonic solutions it can be stated that this type of therapy has not yielded satisfactory results. During recent years increasing evidence has been accumulated on the efficacy of steroids on brain edema. Steroids were reported to result in rapid relief of signs and symptoms of increased intracranial pressure and neurological dysfunction accompanying cerebral edema. It was the aim of this workshop to evaluate the effect of corticosteroids on brain edema as an advance in therapy. It was hoped that this could be achieved by a multi­ disciplinary approach. Though, the volume contains the contributions of various experts - internists, neurochemists, neurologists, neuropathologists, neurosurgeons, pharmacologists, physiologists - who have added considerable experimental and clin­ ical evidence on the action of steroids on brain edema. New pathophysiological aspects regarding the mechanisms underlying the formation and resolution of brain The effectiveness of corticosteroid therapy in various forms edema are presented. of clinical and experimental brain edema, e. g. accompanying brain tumors, head injury, spinal cord injury, cerebrovascular lesions, etc. as well as dosage and duration of treatment are critically discussed.

Editors and Affiliations

  • Neurochirurgische Universitätsklinik Mainz, Mainz, W. Germany

    H. J. Reulen, K. Schürmann

Bibliographic Information

  • Book Title: Steroids and Brain Edema

  • Book Subtitle: Proceedings of an International Workshop, held in Mainz, W. Germany, June 19 to 21, 1972

  • Editors: H. J. Reulen, K. Schürmann

  • DOI: https://doi.org/10.1007/978-3-642-65448-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1972

  • Softcover ISBN: 978-3-540-05958-5Published: 01 January 1972

  • eBook ISBN: 978-3-642-65448-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 306

  • Number of Illustrations: 10 b/w illustrations

  • Topics: Neurosurgery

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