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The Human Gut-Liver-Axis in Health and Disease

  • Compiles all recent information on the complex area of gut-liver interaction in health and disease

  • Includes a number of globally leading researchers in the field among the authors

  • Reviews the basic, technological and clinical perspectives

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-ix
  2. Clinical Aspects of Fatty Liver Disease

    1. Front Matter

      Pages 1-1
    2. Clinical Aspects of Alcoholic Liver Disease

      • Mads Israelsen, Aleksander Krag, Maja Thiele
      Pages 3-21
    3. Adult Non-alcoholic Fatty Liver Disease (NAFLD)

      • Julie Steen Pedersen, Flemming Bendtsen
      Pages 23-46
    4. Impact of Childhood Obesity in Fatty Liver Disease

      • Cilius Esmann Fonvig, Jens-Christian Holm
      Pages 47-64
    5. Fetal Programming of Fatty Liver Disease

      • Charlotte Brøns, Louise Justesen
      Pages 65-80
    6. Health Economics and Fatty Liver Disease

      • Hans Olav Melberg, Lars Asphaug
      Pages 81-86
  3. The Gut Liver Axis in Health and Disease

    1. Front Matter

      Pages 87-87
    2. The Role of the Bacterial Microbiota in Alcoholic and Non-alcoholic Fatty Liver Disease

      • Anne Lundager Madsen, Thorsten Brach, Timo Kern, Emilie Glad Bak, Trine Nielsen, Manimozhiyan Arumugam
      Pages 89-104
    3. Oral Microbiota and Liver Disease

      • Timo Kern, Trine Nielsen
      Pages 105-120
    4. The Role of the Virome in the Gut-Liver Axis

      • Jelle Matthijnssens, Emilie Glad Bak, Shivaprasad Patil, Mahmoud Reza Pourkarim, Andrzej Górski
      Pages 121-131
    5. The Role of the Mycobiota in the Gut-Liver Axis

      • Maria Camila Alvarez-Silva, Thorsten Brach, Asker Daniel Brejnrod, Manimozhiyan Arumugam
      Pages 133-145
    6. The Use of Metabolomics to Explore the Gut-Liver Axis

      • Lars Ove Dragsted, Kajetan TroÅ¡t
      Pages 147-164
    7. Proteomics in the Study of Liver Diseases

      • Lili Niu, Philipp E. Geyer, Matthias Mann
      Pages 165-193
    8. Genetic Aspects of Non-alcoholic Fatty Liver Disease (NAFLD)

      • Stefan Stender, Niels Grarup, Torben Hansen
      Pages 195-206
    9. The Role of microRNAs in the Gut-Liver Axis

      • S. Georgiou, V. Pantazopoulou, Ema Anastasiadou
      Pages 207-234
    10. Animal Models When Examining the Gut-Liver Axis

      • Fernando Magdaleno, Maximilian Joseph Brol, Robert Schierwagen, Frank Erhard Uschner, Michael Zwick, Jonel Trebicka
      Pages 235-264
    11. Extracellular Matrix Remodeling with Focus on Biochemical Markers in Liver Fibrosis: Limitations and Possibilities

      • Mette Juul Nielsen, Morten A. Karsdal, Aleksander Krag, Diana Julie Leeming
      Pages 265-286
  4. Back Matter

    Pages 287-294

About this book

The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere.

The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area.

The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field. 

Editors and Affiliations

  • Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark

    Aleksander Krag

  • The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark

    Torben Hansen

About the editors

Aleksander Krag is a clinical specialist in gastrointestinal and liver diseases where he is Professor and Head of Hepatology at University of Southern Denmark and Odense University Hospital. He is also Director for Centre for Liver Research. Professor Krag is educated from University of Copenhagen, where he also obtained his PhD degree. In addition he has studied leadership and innovation at Harvard Business School. Professor Krag is involved in several international research consortia in the field, including being Coordinator in Galaxy, a Horizon 2020 funded project on gut-liver interactions in liver diseases. He has been invited speaker for scientific meetings in more than 20 different countries and published more than 130 papers on clinical aspects of chronic liver disease. He has for long served in the Scientific Committee of the Baveno Group and the Executive Committee of the International Club of Ascites, to promote research in the field and develop international guidelines. 

Bibliographic Information

  • Book Title: The Human Gut-Liver-Axis in Health and Disease

  • Editors: Aleksander Krag, Torben Hansen

  • DOI: https://doi.org/10.1007/978-3-319-98890-0

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-319-98889-4Published: 20 November 2018

  • eBook ISBN: 978-3-319-98890-0Published: 09 November 2018

  • Edition Number: 1

  • Number of Pages: IX, 294

  • Number of Illustrations: 1 b/w illustrations, 34 illustrations in colour

  • Topics: Gastroenterology, Hepatology, Human Physiology, Endocrinology

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access