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Spectrally Resolved Detector Arrays for Multiplexed Biomedical Fluorescence Imaging

  • Book
  • © 2018

Overview

Authors:
  1. Anna Siri Luthman

    1. Department of Physics, University of Cambridge, Cambridge, United Kingdom

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  • Nominated as an outstanding Ph.D thesis by the University of Cambridge, Cambridge, UK
  • Shows that multiplexed biomedical fluorescence imaging could enable highly sensitive and specific diagnosis, providing the information required for personalized image-guided treatment
  • Discusses spectrally resolved detector arrays (SRDAs), which provide a compact and robust approach to multiplexed biomedical fluorescence imaging
  • Details camera characterizations, calibrations, and system integrations required when implementing spectrally resolved detector arrays in biomedical imaging instrumentation

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Summary and Rationale

    • Anna Siri Luthman
    Pages 1-7

  3. Spectral Imaging Systems and Sensor Characterisations

    • Anna Siri Luthman
    Pages 9-50

  4. Wide-Field fHSI with a Linescan SRDA

    • Anna Siri Luthman
    Pages 51-85

  5. A Multispectral Endoscope Based on SRDAs

    • Anna Siri Luthman
    Pages 87-130

  6. Conclusions and Outlook

    • Anna Siri Luthman
    Pages 131-136

  7. Back Matter

    Pages 137-137
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Keywords

About this book

This book describes the design, development, characterisation and application of two novel fluorescence imaging instruments based on spectrally resolved detector arrays (SRDAs). The simplest SRDA is the standard colour camera, which integrates a Bayer filter array of red, green and blue colour filters to replicate the colour sensing capability of the human eye. The SRDAs used in this book contain many more colours, ranging from 16 to over 100 colour channels. Using these compact, robust and low-cost detectors for biomedical applications opens new avenues of exploration that were not possible before, in particular, the use of spectral imaging in endoscopy. The work presented shows for the first time that not only can this new type of camera be used for fluorescence imaging, but also that it is able to resolve signals from up to 7 different dyes – a level of multiplexing not previously achieved in tissue with such compact and robust equipment. Furthermore, it reports the application of abimodal endoscope performing both reflectance and fluorescence imaging using these cameras in an ex vivo pig oesophagus model.

Authors and Affiliations

  • Department of Physics, University of Cambridge, Cambridge, United Kingdom

    Anna Siri Luthman

About the author

A. Siri Luthman} graduated in 2013 with a first class MSci degree in physics from Imperial College London (London, UK). She received a Ph.D. degree in Physics in 2017 from the University of Cambridge (Cambridge, UK), where her thesis work focused on the use of spectrally resolving detector arrays for multiplexed biomedical fluorescence imaging. She is currently pursuing postodoctoral research within the field of biomedical imaging.

Dr. Luthman was a recipient of the George and Lillian Scholarship and EPSRC Studentship in 2013-2016 and was awarded the Foundation BLANCEFLOR Scholarship in 2016.

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