Autophagy in Health and Disease

1. Front Matter

   Pages i-xi

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2. Autophagy and Stem Cells

   • Kai Li, Zhuo Yang

   Pages 1-20

3. Fine-Tuning the Stem Cell Fate by Autophagy

   • Shalmoli Bhattacharyya, Ajay Kumar

   Pages 21-29

4. Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine

   • Rohan S. Kulkarni, Manmohan Bajaj, Vaijayanti P. Kale

   Pages 31-45

5. Forkhead Box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis

   • Longhua Liu, Zhiyong Cheng

   Pages 47-69

6. The Role of mTOR in Osteoclasts

   • Ralph A. Zirngibl, Irina Voronov

   Pages 71-85

7. Apoptotic Cell Clearance in Gut Tissue: Role of Intestinal Regeneration

   • Yasunao Numata, Daisuke Hirayama, Kohei Wagatsuma, Tomoya Iida, Hiroshi Nakase

   Pages 87-100

8. Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration

   • Toshihiko Aki, Kanako Noritake, Kana Unuma, Koichi Uemura

   Pages 101-118

9. The Role of Autophagy in Mesenchymal Stem Cell-Based Suppression of Immune Response

   • Vladislav Volarevic, Jelena Jakovljevic, C. Randall Harrell, Crissy Fellabaum, Nebojsa Arsenijevic

   Pages 119-133

10. Emerging Connections: Synaptic Autophagy in Brain Aging and Disease

    • YongTian Liang

    Pages 135-152

11. Virus and Autophagy: Enemies or Allies

    • José A. Boga, Zulema Pérez-Martínez, Ana Coto-Montes, Marta E. Alvarez-Argüelles, Russel J. Reiter

    Pages 153-161

12. Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives

    • Bakiye Goker Bagca, Cigir Biray Avci

    Pages 163-177

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. 


The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing cliniciansand advanced graduate students.

• Aging
• Diabetes
• Mitochondria
• Neurodegeneration
• Osteoarthritis
• Cell Cycle Analysis
• metabolic disease

“This is a useful supplement for those studying autophagy and provides important perspectives in basic and translational science. It summarizes the known roles of this process in human biology and provides a current outlook on how a better understanding of autophagy will lead to advances in many areas of medicine.” (Thomas Bodenstine, Doody's Book Reviews, May 03, 2019)

• Ottawa, Canada

  Kursad Turksen

Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen was, until recently, Editor in Chief of the Springer journal Stem Cell Reviews and Reports and currently serves as Series Editor for the Springer series Stem Cell Biology and Regenerative Medicine.

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