Regenerative Medicine and Stem Cell Therapy for the Eye

1. Front Matter

   Pages i-x

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2. Photoreceptor Cell Replacement Therapy from Stem Cells

   • Gilbert Bernier

   Pages 1-16

3. Human Pluripotent Stem Cells as In Vitro Models for Retinal Development and Disease

   • Akshayalakshmi Sridhar, Kirstin B. Langer, Clarisse M. Fligor, Matthew Steinhart, Casey A. Miller, Kimberly T. Ho-A-Lim et al.

   Pages 17-49

4. Bioengineered and Regenerative Medicine Strategies for Retina Repair

   • Linyang Yu, Vianney Delplace, Samantha L. Payne, Molly S. Shoichet

   Pages 51-86

5. Cell and Animal Models used for Retinal Stem Cell Research

   • Michael J. Young, Jea Young Park

   Pages 87-122

6. Limbal Stem Cells and the Treatment of Limbal Stem Cell Deficiency

   • Bruce R. Ksander, Markus H. Frank, Natasha Y. Frank

   Pages 123-148

7. Stem Cell Therapy and Regenerative Medicine in the Cornea

   • Christopher D. McTiernan, Isabelle Brunette, May Griffith

   Pages 149-171

8. Clinical Applications of Limbal Stem Cells for Regenerative Medicine

   • Brian G. Ballios, Allan R. Slomovic

   Pages 173-191

9. Retinal Ganglion Cell Replacement: A Bridge to the Brain

   • Petr Baranov, Julia Oswald

   Pages 193-206

10. Back Matter

    Pages 207-212

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This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation  and cell replacement therapy; gene therapy; and in vitro disease modelling.  Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds indevelopmental biology and bioengineering.   


This book also

• Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease
  
• Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain
  
• Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers
  
• Examines the connection between cell therapy and gene editing, in particular relation to ocular disease
  

• retinal regeneration
• ocular surface stem cell transplantation
• photoreceptors transplantation
• retinal pigment epithelium transplantation
• retinal stem cells
• limbal stem cells
• embryonic stem cells
• induced-pluripotent stem cells

• Department Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada

  Brian G. Ballios

• Schepens Eye Research Institute, Harvard Medical School, Boston, USA

  Michael J. Young

Brian Ballios, M.D., Ph.D., Senior Research Associate and Resident Physician in the Department of Ophthalmology and Vision Sciences, University of Toronto, received his B.Sc.Eng. in Engineering Chemistry from Queen’s University in 2007.  He then completed a combined MD/PhD Program at the University of Toronto in 2015.  During his graduate work, he developed new approaches to the transplantation of stem cells and their progeny for the treatment of retinal degeneration.  His interests lie at the intersection of retinal neurobiology and applied science, as related to stem cell biology and bioengineering.  He developed the first injectable biomaterial-based delivery system for stem cell transplantation in the retina.  In 2016, he joined the Department of Ophthalmology and Vision Sciences as a Senior Research Associate, while also completing an ophthalmology residency.

Michael Young, Ph.D., Associate Scientist at the Schepens Eye Research Institute, received his BS degree in behavioral neuroscience from the University of Pittsburgh in 1989. He then received his PhD in anatomy/neuroscience from the University of Cambridge in 1995. A postdoctoral fellowship at the Institute of Ophthalmology, University College, London in 1995 was followed by a two-year postdoctoral fellowship at the Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences.  In 1998, Young joined the Schepens Eye Research Institute as an Investigator. He was elected the Director of the Minda deGunzburg Center for Ocular Regeneration.  In 2008, he was promoted to Associate Professor in the Department of Ophthalmology, Harvard Medical School. He is now also Co-director of the Ocular Regenerative Medicine Institute at MEE/HMS.

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